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1.
Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.
Bioorg Med Chem
; 27(4): 579-588, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30626555
2.
Hyperpolarized gas diffusion MRI of biphasic lung inflation in short- and long-term emphysema models.
Am J Physiol Lung Cell Mol Physiol
; 313(2): L305-L312, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28473321
3.
Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress.
J Pharmacol Exp Ther
; 363(1): 114-125, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28790194
4.
Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs.
Mutagenesis
; 32(3): 343-353, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27993944
5.
Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.
J Immunol
; 195(10): 4841-52, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26438525
6.
Alveolar Macrophage Distribution in a Mouse Model: The Importance of the Fixation Method.
Toxicol Pathol
; 43(8): 1162-5, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26353977
7.
T cell depletion protects against alveolar destruction due to chronic cigarette smoke exposure in mice.
Am J Physiol Lung Cell Mol Physiol
; 304(5): L312-23, 2013 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23292810
8.
In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor.
Prostaglandins Other Lipid Mediat
; 104-105: 25-31, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23434473
9.
Azepanone-based inhibitors of human cathepsin S: optimization of selectivity via the P2 substituent.
Bioorg Med Chem Lett
; 21(15): 4409-15, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21733692
10.
The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity.
J Pharmacol Exp Ther
; 330(3): 922-31, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19498103
11.
Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement.
Immunol Lett
; 121(1): 13-21, 2008 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-18706444
12.
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
J Clin Invest
; 128(6): 2281-2296, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29533925
13.
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J Med Chem
; 59(8): 3991-4006, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27031670
14.
Regional function-structure relationships in lungs of an elastase murine model of emphysema.
J Appl Physiol (1985)
; 112(1): 135-48, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21940853
15.
Inhibition of invariant chain processing, antigen-induced proliferative responses, and the development of collagen-induced arthritis and experimental autoimmune encephalomyelitis by a small molecule cysteine protease inhibitor.
J Immunol
; 180(12): 7989-8003, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18523262
16.
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation.
J Pharmacol Exp Ther
; 312(1): 373-81, 2005 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-15316093
17.
A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit.
J Immunol
; 169(11): 6435-44, 2002 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12444152
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