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1.
GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species.
J Pharmacol Exp Ther
; 350(1): 153-63, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24784567
2.
Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.
Bioorg Med Chem
; 21(21): 6264-73, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24075145
3.
Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
Bioorg Med Chem Lett
; 21(18): 5562-7, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21831639
4.
Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): in vivo neurochemical and behavioural evidence of anxiolytic/antidepressant activity.
Neuropharmacology
; 50(8): 975-83, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16581092
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