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1.
In Vitro Simulation of the Fasted Gastric Conditions and Their Variability to Elucidate Contrasting Properties of the Marketed Dabigatran Etexilate Pellet-Filled Capsules and Loose Pellets.
Mol Pharm
; 21(5): 2456-2472, 2024 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38568423
2.
Development and verification of mechanistic vaginal absorption and metabolism model to predict systemic exposure after vaginal ring and gel application.
Br J Clin Pharmacol
; 2024 Mar 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38450818
3.
Physiologically based modelling of dermal absorption and kinetics of consumer-relevant chemicals: A case study with exposure to bisphenol A from thermal paper.
Toxicol Appl Pharmacol
; 459: 116357, 2023 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36572228
4.
In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part III.
Int J Mol Sci
; 24(3)2023 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36768563
5.
Artificial Intelligence That Predicts Sensitizing Potential of Cosmetic Ingredients with Accuracy Comparable to Animal and In Vitro Tests-How Does the Infotechnomics Compare to Other "Omics" in the Cosmetics Safety Assessment?
Int J Mol Sci
; 24(7)2023 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37047774
6.
Mechanistic Modeling of In Vitro Skin Permeation and Extrapolation to In Vivo for Topically Applied Metronidazole Drug Products Using a Physiologically Based Pharmacokinetic Model.
Mol Pharm
; 19(9): 3139-3152, 2022 09 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35969125
7.
Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency - Role of physiological and other non-drug related parameters.
J Clin Pharm Ther
; 47(12): 2152-2161, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36068182
8.
In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part II.
Int J Mol Sci
; 23(19)2022 Oct 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36233247
9.
In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part I.
Int J Mol Sci
; 23(21)2022 Oct 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36361773
10.
How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology - model-based case study.
J Pharmacokinet Pharmacodyn
; 48(3): 387-399, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33666801
11.
Magnetic Core-Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma-Material Characterization, Theoretical Analysis and Pharmacokinetics.
Int J Mol Sci
; 22(7)2021 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33915912
12.
Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.
Toxicol Appl Pharmacol
; 390: 114883, 2020 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31981640
13.
Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry.
Int J Mol Sci
; 21(24)2020 Dec 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33353167
14.
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models.
J Appl Toxicol
; 38(4): 450-458, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29143966
15.
Drug-physiology interaction and its influence on the QT prolongation-mechanistic modeling study.
J Pharmacokinet Pharmacodyn
; 45(3): 483-490, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29546612
16.
Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals.
J Pharmacokinet Pharmacodyn
; 45(5): 663-677, 2018 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-29943290
17.
Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development.
J Pharmacokinet Pharmacodyn
; 45(3): 457-467, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29520534
18.
Utilizing postmortem drug concentrations in mechanistic modeling and simulation of cardiac effects: a proof of concept study with methadone.
Toxicol Mech Methods
; 28(8): 555-562, 2018 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-29747546
19.
Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept.
Toxicol Mech Methods
; 27(2): 88-99, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-27813448
20.
Enhanced QSAR models for drug-triggered inhibition of the main cardiac ion currents.
J Appl Toxicol
; 35(9): 1030-9, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25559930