Búsqueda | Biblioteca Virtual en Salud

1.

eIF4E-mediated translational control of cancer incidence.

Bitterman, Peter B; Polunovsky, Vitaly A.

Biochim Biophys Acta ; 1849(7): 774-80, 2015 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-25263391

2.

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.

Avdulov, Svetlana; Li, Shunan; Michalek, Van; Burrichter, David; Peterson, Mark; Perlman, David M; Manivel, J Carlos; Sonenberg, Nahum; Yee, Douglas; Bitterman, Peter B; Polunovsky, Vitaly A.

Cancer Cell ; 5(6): 553-63, 2004 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-15193258

3.

Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.

Larsson, Ola; Li, Shunan; Issaenko, Olga A; Avdulov, Svetlana; Peterson, Mark; Smith, Karen; Bitterman, Peter B; Polunovsky, Vitaly A.

Cancer Res ; 67(14): 6814-24, 2007 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-17638893

4.

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein.

Ghosh, Phalguni; Cheng, Jilin; Chou, Tsui-Fen; Jia, Yan; Avdulov, Svetlana; Bitterman, Peter B; Polunovsky, Vitaly A; Wagner, Carston R.

Protein Expr Purif ; 60(2): 132-9, 2008 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-18479935

5.

Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure.

Larsson, Ola; Perlman, David M; Fan, Danhua; Reilly, Cavan S; Peterson, Mark; Dahlgren, Cecilia; Liang, Zicai; Li, Shunan; Polunovsky, Vitaly A; Wahlestedt, Claes; Bitterman, Peter B.

Nucleic Acids Res ; 34(16): 4375-86, 2006.

Artículo en Inglés | MEDLINE | ID: mdl-16936314

6.

Repression of cap-dependent translation attenuates the transformed phenotype in non-small cell lung cancer both in vitro and in vivo.

Jacobson, Blake A; Alter, Michael D; Kratzke, Marian G; Frizelle, Sandra P; Zhang, Ying; Peterson, Mark S; Avdulov, Svetlana; Mohorn, Riikka P; Whitson, Bryan A; Bitterman, Peter B; Polunovsky, Vitaly A; Kratzke, Robert A.

Cancer Res ; 66(8): 4256-62, 2006 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-16618749

7.

Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency.

Li, Shunan; Sonenberg, Nahum; Gingras, Anne-Claude; Peterson, Mark; Avdulov, Svetlana; Polunovsky, Vitaly A; Bitterman, Peter B.

Mol Cell Biol ; 22(8): 2853-61, 2002 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-11909977

8.

Acquired Tamoxifen Resistance in MCF-7 Breast Cancer Cells Requires Hyperactivation of eIF4F-Mediated Translation.

Fagan, Dedra H; Fettig, Lynsey M; Avdulov, Svetlana; Beckwith, Heather; Peterson, Mark S; Ho, Yen-Yi; Wang, Fan; Polunovsky, Vitaly A; Yee, Douglas.

Horm Cancer ; 8(4): 219-229, 2017 08.

Artículo en Inglés | MEDLINE | ID: mdl-28577281

9.

The cap-dependent translation apparatus integrates and amplifies cancer pathways.

Polunovsky, Vitaly A; Bitterman, Peter B.

RNA Biol ; 3(1): 10-7, 2006.

Artículo en Inglés | MEDLINE | ID: mdl-17114939

10.

eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.

Avdulov, Svetlana; Herrera, Jeremy; Smith, Karen; Peterson, Mark; Gomez-Garcia, Jose R; Beadnell, Thomas C; Schwertfeger, Kathryn L; Benyumov, Alexey O; Manivel, J Carlos; Li, Shunan; Bielinsky, Anja-Katrin; Yee, Douglas; Bitterman, Peter B; Polunovsky, Vitaly A.

Cancer Res ; 75(4): 687-97, 2015 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-25524901

11.

Introduction to Translation.

Polunovsky, Vitaly A; Hershey, John W B; Sonenberg, Nahum.

Translation (Austin) ; 1(1): e24611, 2013.

Artículo en Inglés | MEDLINE | ID: mdl-26824021

12.

Translational control of cell fate: from integration of environmental signals to breaching anticancer defense.

Bitterman, Peter B; Polunovsky, Vitaly A.

Cell Cycle ; 11(6): 1097-107, 2012 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-22356766

13.

Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation.

Bitterman, Peter B; Polunovsky, Vitaly A.

Mol Cancer Ther ; 11(5): 1051-61, 2012 May.

Artículo en Inglés | MEDLINE | ID: mdl-22572598

14.

Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense.

Kim, Yong Y; Von Weymarn, Linda; Larsson, Ola; Fan, Danhua; Underwood, Jon M; Peterson, Mark S; Hecht, Stephen S; Polunovsky, Vitaly A; Bitterman, Peter B.

Cancer Res ; 69(21): 8455-62, 2009 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-19843855

15.

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation.

Ghosh, Brahma; Benyumov, Alexey O; Ghosh, Phalguni; Jia, Yan; Avdulov, Svetlana; Dahlberg, Peter S; Peterson, Mark; Smith, Karen; Polunovsky, Vitaly A; Bitterman, Peter B; Wagner, Carston R.

ACS Chem Biol ; 4(5): 367-77, 2009 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-19351181

16.

mTOR Pathway and mTOR Inhibitors in Cancer Therapy

Polunovsky, Vitaly A.

Totowa, NJ; Humana Press;Imprint: Humana Press; 2010. 304 p.

Monografía en Inglés | Bibliografia | ID: bib-343207

17.

Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP.

Ghosh, Phalguni; Park, Chunkyung; Peterson, Mark S; Bitterman, Peter B; Polunovsky, Vitaly A; Wagner, Carston R.

Bioorg Med Chem Lett ; 15(8): 2177-80, 2005 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-15808492

18.

Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis.

Li, Shunan; Perlman, David M; Peterson, Mark S; Burrichter, David; Avdulov, Svetlana; Polunovsky, Vitaly A; Bitterman, Peter B.

J Biol Chem ; 279(20): 21312-7, 2004 May 14.

Artículo en Inglés | MEDLINE | ID: mdl-14990584

19.

Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.

Li, Shunan; Takasu, Tasaburo; Perlman, David M; Peterson, Mark S; Burrichter, David; Avdulov, Svetlana; Bitterman, Peter B; Polunovsky, Vitaly A.

J Biol Chem ; 278(5): 3015-22, 2003 Jan 31.

Artículo en Inglés | MEDLINE | ID: mdl-12441348

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eIF4E-mediated translational control of cancer incidence.

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.

Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.

Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein.

Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure.

Repression of cap-dependent translation attenuates the transformed phenotype in non-small cell lung cancer both in vitro and in vivo.

Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency.

Acquired Tamoxifen Resistance in MCF-7 Breast Cancer Cells Requires Hyperactivation of eIF4F-Mediated Translation.

The cap-dependent translation apparatus integrates and amplifies cancer pathways.

eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.

Introduction to Translation.

Translational control of cell fate: from integration of environmental signals to breaching anticancer defense.

Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation.

Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense.

Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation.

mTOR Pathway and mTOR Inhibitors in Cancer Therapy

Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP.

Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis.

Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.