Detalles de la búsqueda
1.
Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.
Bioorg Med Chem Lett
; 19(19): 5746-52, 2009 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19726184
2.
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.
Bioorg Med Chem Lett
; 18(9): 2916-9, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18406614
3.
Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors.
Eur J Pharmacol
; 529(1-3): 95-104, 2006 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-16352303
4.
Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist.
J Med Chem
; 46(7): 1273-6, 2003 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-12646038
5.
Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease.
Biochem Pharmacol
; 82(8): 891-903, 2011 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21741954
6.
G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.
Curr Top Med Chem
; 11(15): 1902-24, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21470172
7.
Metabolite identification via LC-SPE-NMR-MS of the in vitro biooxidation products of a lead mGlu5 allosteric antagonist and impact on the improvement of metabolic stability in the series.
ChemMedChem
; 3(1): 136-44, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17994660
8.
Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.
Bioorg Med Chem Lett
; 16(7): 1892-7, 2006 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16439120
9.
Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.
J Neurochem
; 98(2): 601-15, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16805850
10.
An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application.
J Chem Inf Model
; 45(5): 1324-36, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16180909
11.
Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
J Pharmacol Exp Ther
; 315(2): 711-21, 2005 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-16040814
12.
Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.
Mol Pharmacol
; 64(4): 823-32, 2003 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-14500738
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