Detalles de la búsqueda
1.
SARS-CoV-2 variants inactivation of plasma units using a riboflavin and ultraviolet light-based photochemical treatment.
Transfus Apher Sci
; 61(4): 103398, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-35227599
2.
Discovery of Novel Imidazopyridine GSK-3ß Inhibitors Supported by Computational Approaches.
Molecules
; 25(9)2020 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32380735
3.
Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's Disease.
Molecules
; 21(4): 466, 2016 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27070562
4.
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3ß inhibitors.
Angew Chem Int Ed Engl
; 54(5): 1578-82, 2015 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25504761
5.
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.
Bioorg Med Chem Lett
; 23(23): 6254-8, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24140444
6.
Discovery of Novel Chemical Series of OXA-48 ß-Lactamase Inhibitors by High-Throughput Screening.
Pharmaceuticals (Basel)
; 14(7)2021 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-34202402
7.
Development and validation of a simple and versatile method for the quantification of everolimus loaded in H-ferritin nanocages using UHPLC-MS/MS.
J Pharm Biomed Anal
; 191: 113644, 2020 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32987250
8.
Antibacterial activity of novel dual bacterial DNA type II topoisomerase inhibitors.
PLoS One
; 15(2): e0228509, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32074119
9.
Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and In Vivo Activity in a Mood Disorder Model.
ACS Med Chem Lett
; 11(5): 825-831, 2020 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32435391
10.
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.
Eur J Med Chem
; 189: 112047, 2020 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31982652
11.
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.
J Med Chem
; 62(16): 7445-7472, 2019 08 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31276392
12.
Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei.
ChemMedChem
; 14(6): 621-635, 2019 03 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-30664325
13.
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease.
J Med Chem
; 61(3): 619-637, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28749667
14.
Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.
ChemMedChem
; 13(7): 672-677, 2018 04 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29399991
15.
Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.
Drug Discov Today
; 22(1): 43-56, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27793744
16.
Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule.
Chem Biol Drug Des
; 90(2): 225-235, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28079302
17.
From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer's Disease?
J Med Chem
; 59(17): 7759-70, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27124551
18.
Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation.
Expert Opin Ther Targets
; 20(5): 627-40, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26568363
19.
Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease.
ChemMedChem
; 11(12): 1284-95, 2016 06 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-26880501
20.
Rational approach to an antiprion compound with a multiple mechanism of action.
Future Med Chem
; 7(16): 2113-20, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26511069