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1.
Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase.
J Biol Chem
; 299(2): 102856, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36596358
2.
Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases.
Cell Mol Life Sci
; 77(6): 977-996, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-31552448
3.
Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90ß in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery.
Mol Pharmacol
; 94(3): 984-991, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29941666
4.
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.
Annu Rev Pharmacol Toxicol
; 55: 353-71, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25292434
5.
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.
Nat Chem Biol
; 9(2): 112-8, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23222885
6.
Destabilization of the epidermal growth factor receptor (EGFR) by a peptide that inhibits EGFR binding to heat shock protein 90 and receptor dimerization.
J Biol Chem
; 288(37): 26879-86, 2013 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23897823
7.
Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.
J Biol Chem
; 287(2): 1556-65, 2012 Jan 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-22128174
8.
Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.
Biochemistry
; 50(33): 7146-56, 2011 Aug 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21755988
9.
C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination.
J Biol Chem
; 285(44): 33642-51, 2010 Oct 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-20729196
10.
Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.
J Biol Chem
; 285(21): 15714-23, 2010 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-20348093
11.
CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins.
Hum Mol Genet
; 17(24): 3942-52, 2008 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18784277
12.
Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.
Clin Cancer Res
; 26(19): 5246-5257, 2020 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32718999
13.
Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.
Biochemistry
; 48(35): 8483-90, 2009 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-19642705
14.
ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation.
Oncotarget
; 7(50): 82450-82457, 2016 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27738310
15.
Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors.
J Neurosci
; 24(20): 4758-66, 2004 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-15152036
16.
Role of molecular chaperones in steroid receptor action.
Essays Biochem
; 40: 41-58, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-15242338
17.
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement.
Cell Signal
; 16(8): 857-72, 2004 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-15157665
18.
Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation.
Brain Res Mol Brain Res
; 123(1-2): 27-36, 2004 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15046863
19.
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.
Exp Biol Med (Maywood)
; 228(2): 111-33, 2003 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-12563018
20.
A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases.
Exp Biol Med (Maywood)
; 239(11): 1405-13, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24990484