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1.
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Angew Chem Int Ed Engl
; 57(6): 1601-1605, 2018 02 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29284071
2.
Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.
J Immunol
; 193(8): 4245-53, 2014 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25225663
3.
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
Nature
; 461(7262): 411-4, 2009 Sep 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-19727076
4.
Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy.
Clin Cancer Res
; 28(24): 5455-5468, 2022 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36048524
5.
Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.
J Med Chem
; 63(9): 4997-5010, 2020 05 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32338903
6.
Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression.
J Med Chem
; 63(22): 13994-14016, 2020 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33185101
7.
Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression.
J Med Chem
; 62(2): 448-466, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30525597
8.
2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).
Bioorg Med Chem Lett
; 18(23): 6171-4, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18951019
9.
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
Bioorg Med Chem Lett
; 18(24): 6501-4, 2008 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18952427
10.
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.
J Med Chem
; 61(2): 462-481, 2018 01 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28339196
11.
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
J Med Chem
; 61(15): 6685-6704, 2018 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30019901
12.
Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.
J Med Chem
; 61(14): 6110-6120, 2018 07 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-30015487
13.
Discovery of 4-((3'R,4'S,5'R)-6â³-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2â³-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3â³-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development.
J Med Chem
; 60(7): 2819-2839, 2017 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28339198
14.
Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.
Cancer Res
; 77(9): 2476-2487, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28209615
15.
A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040.
Neoplasia
; 7(4): 336-47, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15967111
16.
Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling.
J Exp Med
; 212(5): 729-42, 2015 May 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-25847945
17.
N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain.
Bioorg Med Chem Lett
; 17(16): 4599-603, 2007 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17562362
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