Detalles de la búsqueda
1.
Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study.
Regul Toxicol Pharmacol
; 81: 212-222, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27569204
2.
Nonclinical Safety Profile of Etelcalcetide, a Novel Peptide Calcimimetic for the Treatment of Secondary Hyperparathyroidism.
Int J Toxicol
; 35(3): 294-308, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26941242
3.
High hematocrit resulting from administration of erythropoiesis-stimulating agents is not fully predictive of mortality or toxicities in preclinical species.
Toxicol Pathol
; 42(3): 510-23, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-23674390
4.
Dose-related differences in the pharmacodynamic and toxicologic response to a novel hyperglycosylated analog of recombinant human erythropoietin in Sprague-Dawley rats with similarly high hematocrit.
Toxicol Pathol
; 42(3): 524-39, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-23674391
5.
Cytokines associated with increased erythropoiesis in Sprague-Dawley rats administered a novel hyperglycosylated analog of recombinant human erythropoietin.
Toxicol Pathol
; 42(3): 540-54, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-23674392
6.
Global recognition of qualified toxicologic pathologists: credential review as a potential route for recognizing the proficiency of pathologists involved in regulatory-type nonclinical studies.
Toxicol Pathol
; 37(4): 553-61, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19458391
7.
Global Recognition of Qualified Toxicologic Pathologists: Credential Review as a Potential Route for Recognizing the Proficiency of Pathologists Involved in Regulatory-type Nonclinical Studies.
J Toxicol Pathol
; 22(2): 143-52, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22271988
8.
Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.
Mol Cancer Ther
; 7(3): 590-8, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18347145
9.
Global recognition of qualified toxicologic pathologists: where we are now and where we need to go.
Toxicol Pathol
; 36(5): 753-9, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18648095
10.
Global recognition of qualified toxicologic pathologists: where we are now and where we need to go.
Exp Toxicol Pathol
; 60(1): 1-8, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18424010
11.
Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody.
Bone Rep
; 8: 90-94, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29955626
12.
Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats.
Bone Rep
; 8: 95-103, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29955627
13.
Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys.
J Bone Miner Res
; 32(4): 788-801, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27865001
14.
Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.
Bone
; 84: 148-159, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26721737
15.
Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats.
J Bone Miner Res
; 30(8): 1457-67, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25678055
16.
Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats.
Bone
; 81: 380-391, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26261096
17.
The international nomenclature project: an update.
Toxicol Pathol
; 37(5): 694-7, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19638442
18.
Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy.
Reprod Toxicol
; 48: 132-7, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24859271
19.
Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period.
Bone
; 64: 314-25, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24727159
20.
Reproductive toxicity of denosumab in cynomolgus monkeys.
Reprod Toxicol
; 42: 27-40, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23886817