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1.
Synthesis and evaluation of hydrazinyl-containing pyrrolo[2,3-d]pyrimidine series as potent, selective and oral JAK1 inhibitors for the treatment of rheumatoid arthritis.
Bioorg Med Chem Lett
; 74: 128905, 2022 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35870730
2.
The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement.
Bioorg Med Chem Lett
; 30(14): 127240, 2020 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32527542
3.
Accelerating effect of triazolyl and related heteroaryl substituents on SNAr reactions: evidence of hydrogen-bond stabilized transition states.
J Am Chem Soc
; 137(38): 12261-8, 2015 Sep 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-26321078
4.
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious ß-secretase inhibitors for the potential treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 25(4): 767-74, 2015 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25613679
5.
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 23(23): 6447-54, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24139583
6.
Copper-catalyzed domino cycloaddition/C-N coupling/cyclization/(C-H arylation): an efficient three-component synthesis of nitrogen polyheterocycles.
Angew Chem Int Ed Engl
; 52(42): 10992-6, 2013 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-24014265
7.
A new wave of innovations within the DNA damage response.
Signal Transduct Target Ther
; 8(1): 338, 2023 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37679326
8.
Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency.
Bioorg Med Chem Lett
; 22(2): 1061-7, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22197141
9.
Identification of TUL01101: A Novel Potent and Selective JAK1 Inhibitor for the Treatment of Rheumatoid Arthritis.
J Med Chem
; 65(24): 16716-16740, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36512734
10.
3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation.
Bioorg Med Chem Lett
; 21(11): 3384-9, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21514825
11.
Aryl sulfonamides containing tetralin allylic amines as potent and selective bradykinin B1 receptor antagonists.
Bioorg Med Chem Lett
; 20(15): 4593-7, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20573508
12.
Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists.
Bioorg Med Chem Lett
; 18(16): 4477-81, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18674903
13.
Aryl sulfones as novel bradykinin B1 receptor antagonists for treatment of chronic pain.
Bioorg Med Chem Lett
; 18(17): 4764-9, 2008 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18706809
14.
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aß Reduction without Cardiovascular Liabilities.
ACS Med Chem Lett
; 6(2): 210-5, 2015 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25699151
15.
Synthesis of the ABCD Ring System of Azaspiracid.
Angew Chem Int Ed Engl
; 40(21): 4068-4071, 2001 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29712267
16.
One-pot synthesis of 3-triazolyl-2-iminochromenes via a catalytic three component cascade reaction.
Org Lett
; 15(12): 2986-9, 2013 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-23751086
17.
A "click and activate" approach in one-pot synthesis of a triazolyl-pyridazinone library.
Org Lett
; 13(7): 1682-5, 2011 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21351762
18.
Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis.
Angew Chem Int Ed Engl
; 42(31): 3649-53, 2003 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-12916037
19.
Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments.
Angew Chem Int Ed Engl
; 42(31): 3643-8, 2003 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-12916036
20.
Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.
Angew Chem Int Ed Engl
; 40(21): 4068-4071, 2001 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12404495