Detalles de la búsqueda
1.
7ß-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues.
Bioorg Med Chem
; 26(14): 4254-4263, 2018 08 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30054192
2.
Pharmacophore-based design and discovery of (-)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis.
J Enzyme Inhib Med Chem
; 32(1): 659-671, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28274151
3.
Determination of Meserine, a new candidate for Alzheimer's disease in mice brain by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic and tissue distribution study.
Anal Bioanal Chem
; 406(14): 3451-8, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24756818
4.
Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property.
Toxicol Appl Pharmacol
; 264(1): 65-72, 2012 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22842334
5.
SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity.
J Med Chem
; 65(15): 10377-10392, 2022 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35900351
6.
Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.
J Med Chem
; 64(16): 12414-12433, 2021 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34387468
7.
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based κ Opioid Receptor (κOR) Agonists Using the Strategy of Bridging.
ACS Chem Neurosci
; 12(6): 1018-1030, 2021 03 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33650843
8.
Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.
Bioorg Med Chem Lett
; 20(1): 418-21, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19932964
9.
3-[(3S)-3-Ethyl-1-methyl-azepan-3-yl]phenyl N-(4-fluoro-phen-yl)carbamate.
Acta Crystallogr Sect E Struct Rep Online
; 66(Pt 7): o1822, 2010 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-21588029
10.
(3S,4R)-3-Ethyl-4-hydr-oxy-3-(3-methoxy-phen-yl)-1-methyl-azepanium (2R,3R)-2,3-bis-(benzo-yloxy)-3-carboxy-propionate.
Acta Crystallogr Sect E Struct Rep Online
; 66(Pt 5): o1092, 2010 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-21579145
11.
Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice.
Int J Neuropsychopharmacol
; 12(10): 1409-19, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19460190
12.
1-Ethyl-4-hydr-oxy-9-aza-tricyclo-[7.4.1.0]tetra-deca-2,4,6-trien-8-one.
Acta Crystallogr Sect E Struct Rep Online
; 65(Pt 12): o3008, 2009 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-21578746
13.
2-Methyl-1,2,3,4-tetra-hydro-isoquinolin-6-yl N-phenyl-carbamate.
Acta Crystallogr Sect E Struct Rep Online
; 65(Pt 5): o1058, 2009 Apr 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-21583875
14.
Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of ß-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease.
Front Aging Neurosci
; 11: 3, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30723404
15.
Discovery of a Highly Selective and Potent κ Opioid Receptor Agonist from N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept.
J Med Chem
; 62(24): 11054-11070, 2019 12 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31738550
16.
Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.
J Med Chem
; 51(7): 2027-36, 2008 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18333606
17.
(3S,4S)-3-Ethyl-4-hydr-oxy-3-(3-methoxy-phen-yl)-1-methyl-azepan-1-ium d-tartrate dihydrate.
Acta Crystallogr Sect E Struct Rep Online
; 64(Pt 5): o784, 2008 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-21202277
18.
(E)-6-Meth-oxy-9-methyl-1,2,3,4-tetra-hydro-9H-carbazol-4-one oxime.
Acta Crystallogr Sect E Struct Rep Online
; 64(Pt 8): o1418, 2008 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-21203137
19.
Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice.
Transl Neurodegener
; 7: 21, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30237878
20.
The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent κ-Opioid Agonistic Activities.
ACS Chem Neurosci
; 8(4): 766-776, 2017 04 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-28033462