Detalles de la búsqueda
1.
Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer.
N Engl J Med
; 381(21): 2020-2031, 2019 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31562796
2.
Antitumor activity of GSK1904529A, a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase.
Clin Cancer Res
; 15(9): 3058-67, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19383820
3.
Synthesis, SAR study and biological evaluation of novel pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as anti-proliferative agents.
Bioorg Med Chem
; 17(5): 2091-100, 2009 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19200741
4.
4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4 (CDK4).
J Med Chem
; 51(12): 3507-25, 2008 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-18494457
5.
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase.
Cancer Res
; 64(11): 3958-65, 2004 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15173008
6.
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.
J Med Chem
; 48(4): 1107-31, 2005 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15715478
7.
Antitumor activity of HER-2 inhibitors.
Cancer Lett
; 227(1): 9-23, 2005 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-16051028
8.
Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2).
J Med Chem
; 46(1): 49-63, 2003 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-12502359
9.
Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.
PLoS One
; 9(6): e100880, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24978597
10.
Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
J Med Chem
; 54(6): 1871-95, 2011 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21341675
11.
Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.
J Med Chem
; 52(8): 2289-310, 2009 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-19317452
12.
GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.
Mol Cancer Ther
; 8(10): 2811-20, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19825801
13.
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: exploration of core and headpiece structure-activity relationships.
Bioorg Med Chem Lett
; 17(6): 1641-5, 2007 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17275298
14.
Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression.
Breast Cancer Res Treat
; 95(2): 185-94, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16319987
15.
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.
Proc Natl Acad Sci U S A
; 103(20): 7817-22, 2006 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-16672372
16.
Inhibition of tumor cell proliferation by thieno[2,3-d]pyrimidin-4(1H)-one-based analogs.
Bioorg Med Chem Lett
; 15(16): 3763-6, 2005 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16005212
17.
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region.
Bioorg Med Chem Lett
; 15(6): 1591-4, 2005 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15745803
18.
Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells.
Bioorg Med Chem Lett
; 15(21): 4731-5, 2005 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16143523
19.
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib.
Proc Natl Acad Sci U S A
; 102(21): 7665-70, 2005 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15897464
20.
4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors.
Bioorg Med Chem Lett
; 12(3): 423-5, 2002 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11814812