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1.
Potent and selective bivalent inhibitors of BET bromodomains.
Nat Chem Biol
; 12(12): 1097-1104, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27775716
2.
Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer.
Bioorg Med Chem Lett
; 23(7): 1945-8, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23466225
3.
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
J Med Chem
; 65(4): 3306-3331, 2022 02 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35133824
4.
Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer.
Bioorg Med Chem Lett
; 21(18): 5442-5, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21782422
5.
Data mining of NCI's anticancer screening database reveals mitochondrial complex I inhibitors cytotoxic to leukemia cell lines.
Biochem Pharmacol
; 73(3): 331-40, 2007 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17109823
6.
Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
ACS Med Chem Lett
; 7(1): 94-9, 2016 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26819673
7.
Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
J Med Chem
; 59(17): 7801-17, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27528113
8.
AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.
Mol Cancer Ther
; 15(11): 2563-2574, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27573426
9.
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Cancer Res
; 76(11): 3307-18, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27020862
10.
Linking tumor cell cytotoxicity to mechanism of drug action: an integrated analysis of gene expression, small-molecule screening and structural databases.
Proteins
; 59(3): 403-33, 2005 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15778971
11.
Molecular classification of cancer: unsupervised self-organizing map analysis of gene expression microarray data.
Mol Cancer Ther
; 2(3): 317-32, 2003 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-12657727
12.
Establishing connections between microarray expression data and chemotherapeutic cancer pharmacology.
Mol Cancer Ther
; 1(5): 311-20, 2002 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-12489847
13.
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J Med Chem
; 58(20): 8128-40, 2015 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-26407012
14.
Application of high-throughput, molecular-targeted screening to anticancer drug discovery.
Curr Top Med Chem
; 2(3): 229-46, 2002 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-11944818
15.
Mining the National Cancer Institute's tumor-screening database: identification of compounds with similar cellular activities.
J Med Chem
; 45(4): 818-40, 2002 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-11831894
16.
Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data.
Bioinformatics
; 19(17): 2212-24, 2003 Nov 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-14630650
17.
Mining the NCI screening database: explorations of agents involved in cell cycle regulation.
Prog Cell Cycle Res
; 5: 173-9, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-14593711
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