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1.
Connectivity between surface and interior in catalytic subunits of acetylcholinesterases inferred from their X-ray structures.
J Neurochem
; 168(4): 386-396, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-36892323
2.
The Cyclic Imine Core Common to the Marine Macrocyclic Toxins Is Sufficient to Dictate Nicotinic Acetylcholine Receptor Antagonism.
Mar Drugs
; 22(4)2024 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-38667766
3.
Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects.
J Biol Chem
; 297(3): 101007, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34324828
4.
Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.
J Biol Chem
; 295(13): 4079-4092, 2020 03 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-32019865
5.
Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical.
J Neurochem
; 158(6): 1217-1222, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33638151
6.
Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures.
J Pharmacol Exp Ther
; 378(3): 315-321, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34145064
7.
Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase.
J Biol Chem
; 294(27): 10607-10618, 2019 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31138650
8.
Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.
Toxicol Appl Pharmacol
; 372: 40-46, 2019 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30978400
9.
Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.
Chemistry
; 25(16): 4100-4114, 2019 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30458057
10.
Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.
J Pharmacol Exp Ther
; 367(2): 363-372, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30190337
11.
Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity.
Arch Toxicol
; 92(3): 1161-1176, 2018 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-29167930
12.
Butyrylcholinesterase identification in a phenylvalerate esterase-enriched fraction sensitive to low mipafox concentrations in chicken brain.
Arch Toxicol
; 91(2): 909-919, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26838044
13.
Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation.
Arch Toxicol
; 91(8): 2837-2847, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-27990564
14.
Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.
Proc Natl Acad Sci U S A
; 111(29): 10749-54, 2014 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-25006260
15.
Correction: Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.
J Biol Chem
; 295(19): 6784, 2020 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32385098
16.
Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system.
Toxicol Appl Pharmacol
; 284(2): 197-203, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25701203
17.
Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes.
Chem Res Toxicol
; 28(5): 1036-44, 2015 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-25835984
18.
Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.
Biochem J
; 450(1): 231-42, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23216060
19.
Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.
J Biol Chem
; 287(15): 11798-809, 2012 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-22343626
20.
Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase.
J Chem Inf Model
; 53(4): 898-906, 2013 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23451944