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1.
Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics.
Molecules
; 25(20)2020 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-33092129
2.
Convulsant Effects of Abused Synthetic Cannabinoids JWH-018 and 5F-AB-PINACA Are Mediated by Agonist Actions at CB1 Receptors in Mice.
J Pharmacol Exp Ther
; 368(2): 146-156, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30420360
3.
Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22).
Xenobiotica
; 49(12): 1388-1395, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30739533
4.
Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants.
Biochem Biophys Res Commun
; 498(3): 597-602, 2018 04 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29522717
5.
A potential role for human UDP-glucuronosyltransferase 1A4 promoter single nucleotide polymorphisms in the pharmacogenomics of tamoxifen and its derivatives.
Drug Metab Dispos
; 42(9): 1392-400, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24917585
6.
Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases.
Chem Res Toxicol
; 27(4): 536-45, 2014 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24571610
7.
Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells.
J Appl Toxicol
; 34(11): 1188-99, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25220893
8.
Targeted metabolomic approach for assessing human synthetic cannabinoid exposure and pharmacology.
Anal Chem
; 85(19): 9390-9, 2013 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23987522
9.
CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen.
Biochem Biophys Res Commun
; 441(2): 339-43, 2013 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24148245
10.
Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
Drug Metab Dispos
; 41(2): 414-21, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23160818
11.
Analysis of R- and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases.
J Pharmacol Exp Ther
; 340(1): 46-55, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21972237
12.
Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
Drug Metab Dispos
; 40(9): 1736-43, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22659092
13.
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
Drug Metab Dispos
; 40(11): 2174-84, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22904561
14.
A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors.
Chem Res Toxicol
; 25(4): 825-7, 2012 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-22404317
15.
Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors.
Xenobiotica
; 42(2): 139-56, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21970716
16.
Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine.
Anal Chem
; 83(16): 6381-8, 2011 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21740038
17.
Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine.
Anal Chem
; 83(11): 4228-36, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21506519
18.
Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases.
Drug Metab Dispos
; 39(10): 1967-76, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21746969
19.
Flavin monooxygenases, FMO1 and FMO3, not cytochrome P450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells.
Xenobiotica
; 41(12): 1044-55, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21859392
20.
Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development.
Life Sci
; 285: 119993, 2021 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34592231