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1.
Molecular mechanism of interspecies differences in the binding affinity of TD139 to Galectin-3.
Glycobiology
; 31(10): 1390-1400, 2021 11 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34228782
2.
Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
J Pharmacol Exp Ther
; 376(1): 29-39, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33127749
3.
Identification and stratification of systemic lupus erythematosus patients into two transcriptionally distinct clusters based on IFN-I signature.
Lupus
; 30(5): 762-774, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-33497307
4.
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.
J Pharmacol Exp Ther
; 363(3): 377-393, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28954811
5.
Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system.
Drug Metab Dispos
; 42(3): 369-76, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24335510
6.
Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure.
J Med Chem
; 67(11): 9731-9744, 2024 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38807539
7.
Crystal structure of rat intestinal alkaline phosphatase--role of crown domain in mammalian alkaline phosphatases.
J Struct Biol
; 184(2): 182-92, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24076154
8.
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4534-4564, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35261239
9.
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4457-4480, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35257579
10.
Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus.
J Psychopharmacol
; 33(1): 25-36, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30484737
11.
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
J Med Chem
; 51(12): 3388-413, 2008 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-18498150
12.
Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.
Anal Biochem
; 383(2): 217-25, 2008 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18801329
13.
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.
Bioorg Med Chem
; 16(3): 1345-58, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17998165
14.
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.
ACS Med Chem Lett
; 9(5): 472-477, 2018 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29795762
15.
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
J Med Chem
; 50(6): 1380-400, 2007 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17305324
16.
Modulation of Kv 11.1 (hERG) channels by 5-(((1H-indazol-5-yl)oxy)methyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine (ITP-2), a novel small molecule activator.
Br J Pharmacol
; 174(15): 2484-2500, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28500657
17.
Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment.
Pharmacol Biochem Behav
; 161: 53-61, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28911960
18.
High-throughput screening for the discovery of inhibitors of fatty acid amide hydrolase using a microsome-based fluorescent assay.
J Biomol Screen
; 11(5): 519-27, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16760367
19.
A novel scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening.
Anal Biochem
; 354(1): 35-42, 2006 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16707086
20.
A fluorescence-based assay for fatty acid amide hydrolase compatible with high-throughput screening.
Anal Biochem
; 343(1): 143-51, 2005 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16018870