Detalles de la búsqueda
1.
Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).
Bioorg Med Chem Lett
; 22(7): 2510-3, 2012 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22370270
2.
3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Bioorg Med Chem Lett
; 22(5): 1980-4, 2012 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22318159
3.
1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Bioorg Med Chem Lett
; 21(18): 5301-4, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21813276
4.
1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Bioorg Med Chem Lett
; 21(18): 5234-8, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21824773
5.
2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI.
Bioorg Med Chem Lett
; 19(18): 5359-62, 2009 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19682900
6.
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.
J Med Chem
; 55(7): 3488-501, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22420844
7.
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.
J Med Chem
; 55(2): 943-55, 2012 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22175766
8.
Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.
Eur J Med Chem
; 55: 94-107, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22840695
9.
1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.
J Med Chem
; 55(6): 2882-93, 2012 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-22335555
10.
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
J Med Chem
; 54(20): 7408-16, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21923116
11.
Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.
J Med Chem
; 54(15): 5562-75, 2011 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-21699209
12.
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Bioorg Med Chem Lett
; 17(9): 2540-4, 2007 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17317165
13.
Identification of a novel non-carbohydrate molecule that binds to the ribosomal A-site RNA.
Bioorg Med Chem Lett
; 14(24): 5987-90, 2004 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-15546714
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