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1.
Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M3 Receptor Antagonist/ß 2-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile.
J Pharmacol Exp Ther
; 370(1): 127-136, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31085697
2.
Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /ß2-adrenoceptor agonist (MABA) molecule.
Pulm Pharmacol Ther
; 46: 1-10, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28729041
3.
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists.
Bioorg Med Chem Lett
; 25(8): 1736-1741, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25800115
4.
The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide.
Pulm Pharmacol Ther
; 28(2): 114-21, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24928173
5.
Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern.
bioRxiv
; 2024 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38766244
6.
Pharmacological characterization of abediterol, a novel inhaled ß(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models.
J Pharmacol Exp Ther
; 342(2): 497-509, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22588259
7.
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Bioorg Med Chem Lett
; 21(11): 3457-61, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21524581
8.
Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.
J Pharmacol Exp Ther
; 331(2): 740-51, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19710368
9.
Abediterol (LAS100977), an inhaled long-acting ß2-adrenoceptor agonist, has a fast association rate and long residence time at receptor.
Eur J Pharmacol
; 819: 89-97, 2018 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29183838
10.
In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting ß2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol.
Eur J Pharmacol
; 770: 61-9, 2016 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26656755
11.
Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: in vitro plasma inactivation and pharmacological activity of its main metabolites.
Eur J Pharm Sci
; 39(5): 283-90, 2010 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-20093184
12.
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
J Med Chem
; 52(16): 5076-92, 2009 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-19653626
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