Detalles de la búsqueda
1.
Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions.
Pharmacol Rev
; 74(2): 387-438, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35302046
2.
Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic.
J Pharmacol Exp Ther
; 388(2): 273-300, 2024 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37977814
3.
Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents.
J Pharmacol Exp Ther
; 388(2): 260-267, 2024 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38233227
4.
Long-Term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids.
J Pharmacol Exp Ther
; 388(2): 451-468, 2024 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37863488
5.
Protective Activity of Novel Hydrophilic Synthetic Neurosteroids on Organophosphate Status Epilepticus-induced Chronic Epileptic Seizures, Non-Convulsive Discharges, High-Frequency Oscillations, and Electrographic Ictal Biomarkers.
J Pharmacol Exp Ther
; 388(2): 386-398, 2024 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38050069
6.
A Pediatric Rat Model of Organophosphate-Induced Refractory Status Epilepticus: Characterization of Long-Term Epileptic Seizure Activity, Neurologic Dysfunction and Neurodegeneration.
J Pharmacol Exp Ther
; 388(2): 416-431, 2024 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37977810
7.
Sex Differences in Organophosphate Model of Benzodiazepine-Refractory Status Epilepticus and Neuronal Damage.
J Pharmacol Exp Ther
; 388(2): 313-324, 2024 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37770202
8.
Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-Induced Long-Term Neurological Dysfunction, Neurodegeneration, and Neuroinflammation.
J Pharmacol Exp Ther
; 388(2): 399-415, 2024 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38071567
9.
Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies.
Pharmacol Rev
; 72(4): 767-800, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32817274
10.
Therapeutic Basis of Generic Substitution of Antiseizure Medications.
J Pharmacol Exp Ther
; 381(2): 188-196, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35241634
11.
Experimental and Clinical Biomarkers for Progressive Evaluation of Neuropathology and Therapeutic Interventions for Acute and Chronic Neurological Disorders.
Int J Mol Sci
; 23(19)2022 Oct 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36233034
12.
Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam.
J Pharmacol Exp Ther
; 372(3): 285-298, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31843812
13.
Special Section on Medical Countermeasures, From Bench to Battlefield: Translating Experimental Therapies for Effective Combat Against Chemical Threats-Editorial.
J Pharmacol Exp Ther
; 388(2): 257-259, 2024 01 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38233225
14.
Extrasynaptic γ-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures.
Epilepsia
; 60(4): 730-743, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30895610
15.
Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy.
Int J Mol Sci
; 20(1)2019 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30626103
16.
Benzodiazepine-refractory status epilepticus, neuroinflammation, and interneuron neurodegeneration after acute organophosphate intoxication.
Biochim Biophys Acta Mol Basis Dis
; 1864(9 Pt B): 2845-2858, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29802961
17.
Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.
J Pharmacol Exp Ther
; 367(2): 302-321, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30115757
18.
Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy.
J Pharmacol Exp Ther
; 364(2): 180-197, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29142081
19.
3ß-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic δ-Subunit γ-Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield.
J Pharmacol Exp Ther
; 365(3): 583-601, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29602830
20.
Epigenetic Histone Deacetylation Inhibition Prevents the Development and Persistence of Temporal Lobe Epilepsy.
J Pharmacol Exp Ther
; 364(1): 97-109, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29101217