Detalles de la búsqueda
1.
Learning from Protein Engineering by Deconvolution of Multi-Mutational Variants.
Angew Chem Int Ed Engl
; : e202404880, 2024 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38884594
2.
The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions.
J Am Chem Soc
; 143(37): 14939-14950, 2021 09 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34491742
3.
Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation.
Chembiochem
; 22(5): 904-914, 2021 03 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33094545
4.
Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability.
Chem Rev
; 119(3): 1626-1665, 2019 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30698416
5.
P450-BM3-Catalyzed Sulfoxidation versus Hydroxylation: A Common or Two Different Catalytically Active Species?
J Am Chem Soc
; 142(4): 2068-2073, 2020 01 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-31927987
6.
Directed Evolution of Artificial Metalloenzymes: A Universal Means to Tune the Selectivity of Transition Metal Catalysts?
Acc Chem Res
; 52(2): 336-344, 2019 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30689339
7.
The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes.
Angew Chem Int Ed Engl
; 59(32): 13204-13231, 2020 08 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31267627
8.
Regio- and Stereoselective Steroid Hydroxylation at C7 by Cytochromeâ P450 Monooxygenase Mutants.
Angew Chem Int Ed Engl
; 59(30): 12499-12505, 2020 07 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-32243054
9.
Exploiting Designed Oxidase-Peroxygenase Mutual Benefit System for Asymmetric Cascade Reactions.
J Am Chem Soc
; 141(14): 5655-5658, 2019 04 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30920820
10.
Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters.
J Am Chem Soc
; 141(19): 7934-7945, 2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31023008
11.
Manipulating the stereoselectivity of a thermostable alcohol dehydrogenase by directed evolution for efficient asymmetric synthesis of arylpropanols.
Biol Chem
; 400(3): 313-321, 2019 02 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-30269104
12.
Chemical and Biocatalytic Routes to Arbutin .
Molecules
; 24(18)2019 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31514332
13.
Chemo- and Regioselective Dihydroxylation of Benzene to Hydroquinone Enabled by Engineered Cytochromeâ P450 Monooxygenase.
Angew Chem Int Ed Engl
; 58(3): 764-768, 2019 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30511432
14.
Hinge-Type Dimerization of Proteins by a Tetracysteine Peptide of High Pairing Specificity.
Biochemistry
; 57(26): 3658-3664, 2018 07 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29863338
15.
Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution.
J Am Chem Soc
; 140(33): 10464-10472, 2018 08 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-30044629
16.
Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations.
J Am Chem Soc
; 140(1): 310-318, 2018 01 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29232125
17.
Solid-Phase Gene Synthesis for Mutant Library Construction: The Future of Directed Evolution?
Chembiochem
; 19(19): 2023-2032, 2018 10 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30044530
18.
Clarifying the Difference between Iterative Saturation Mutagenesis as a Rational Guide in Directed Evolution and OmniChange as a Gene Mutagenesis Technique.
Chembiochem
; 19(24): 2542-2544, 2018 12 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-30408315
19.
Methodology Development in Directed Evolution: Exploring Options when Applying Triple-Code Saturation Mutagenesis.
Chembiochem
; 19(3): 239-246, 2018 02 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29314451
20.
Beating Bias in the Directed Evolution of Proteins: Combining High-Fidelity on-Chip Solid-Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial Library Construction.
Chembiochem
; 19(3): 221-228, 2018 02 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29171900