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1.
Dose-dependent exposure and metabolism of GNE-892, a ß-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp.
Eur J Drug Metab Pharmacokinet
; 40(2): 171-85, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24696325
2.
Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing.
Drug Metab Dispos
; 41(7): 1319-28, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23584887
3.
Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.
Cancer Chemother Pharmacol
; 89(6): 737-750, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35435471
4.
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.
Bioorg Med Chem Lett
; 20(18): 5544-7, 2010 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20708930
5.
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
J Med Chem
; 51(6): 1668-80, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18324759
6.
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
J Med Chem
; 51(6): 1649-67, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18324761
7.
Pharmacokinetic characteristics of fentanyl iontophoretic trandermal system over a range of applied current.
Expert Opin Drug Metab Toxicol
; 11(4): 481-9, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25728546
8.
Qualification and application of a liquid chromatography-tandem mass spectrometric method for the determination of human Aß1-40 and Aß1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction.
Arch Pharm Res
; 37(5): 636-44, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23888333
9.
8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors.
J Med Chem
; 57(23): 10112-29, 2014 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25411915
10.
Discovery of 7-tetrahydropyran-2-yl chromans: ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid ß-protein (Aß) in the central nervous system.
J Med Chem
; 57(3): 878-902, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24397738
11.
Spirocyclic ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid ß in a higher species.
J Med Chem
; 56(8): 3379-403, 2013 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-23537249
12.
Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.
Chem Res Toxicol
; 19(2): 279-87, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16485904
13.
Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.
Bioorg Med Chem Lett
; 16(14): 3713-8, 2006 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16697190
14.
Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching.
Drug Metab Dispos
; 33(12): 1837-44, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16135658
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