Detalles de la búsqueda
1.
Pharmacologic characterization of atogepant: A potent and selective calcitonin gene-related peptide receptor antagonist.
Cephalalgia
; 44(1): 3331024231226186, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38215228
2.
Autonomic Dysfunction Linked to Inhibition of the Nav1.7 Sodium Channel.
Circulation
; 149(17): 1394-1396, 2024 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38648272
3.
Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin GeneâRelated Peptide Receptor.
J Pharmacol Exp Ther
; 2020 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-31992609
4.
Assessment of the clinical cardiac drug-drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys.
Hepatology
; 64(5): 1430-1441, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27474787
5.
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Bioorg Med Chem Lett
; 27(4): 1062-1069, 2017 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28131713
6.
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments.
J Pharmacol Toxicol Methods
; : 107525, 2024 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38851600
7.
Structure Guided Discovery of Novel Pan Metallo-ß-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J Med Chem
; 67(5): 3400-3418, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38387069
8.
Comparison of the intrinsic vasorelaxant and inotropic effects of the antiarrhythmic agents vernakalant and flecainide in human isolated vascular and cardiac tissues.
J Cardiovasc Pharmacol
; 61(3): 226-32, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23188129
9.
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis.
J Pharmacol Toxicol Methods
; 124: 107476, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37931824
10.
Development and characterization of canine-specific computational models to predict pulsatile arterial hemodynamics and ventricular-arterial coupling.
Physiol Rep
; 11(11): e15731, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37269177
11.
Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve.
Channels (Austin)
; 16(1): 230-243, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36239534
12.
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
J Med Chem
; 65(1): 485-496, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34931831
13.
Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.
J Neurochem
; 118(6): 1016-31, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21736568
14.
Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist.
J Pharmacol Exp Ther
; 333(1): 152-60, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20065019
15.
Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats.
J Cardiovasc Pharmacol
; 56(5): 518-25, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20729756
16.
Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries.
J Cardiovasc Pharmacol
; 55(5): 518-21, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20164785
17.
Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.
Bioorg Med Chem Lett
; 20(8): 2493-6, 2010 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20304642
18.
Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.
J Pharmacol Exp Ther
; 328(2): 571-8, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18997059
19.
Attenuation of edema and infarct volume following focal cerebral ischemia by early but not delayed administration of a novel small molecule KDR kinase inhibitor.
Neurosci Res
; 63(1): 10-6, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18951929
20.
The prototype serotonin 5-HT 1B/1D agonist sumatriptan increases the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.
J Cardiovasc Pharmacol
; 53(6): 474-9, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19430309