Detalles de la búsqueda
1.
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.
Pharm Res
; 39(7): 1321-1341, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35411506
2.
Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat.
Drug Metab Dispos
; 49(1): 53-61, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33148688
3.
Concentration Dependence of the Unbound Partition Coefficient Kpuu and Its Application to Correct for Exposure-Related Discrepancies between Biochemical and Cellular Potency of KAT6A Inhibitors.
Drug Metab Dispos
; 48(7): 553-562, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32357973
4.
Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.
Proc Natl Acad Sci U S A
; 114(44): 11745-11750, 2017 10 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-29078330
5.
Quantitation of Lysosomal Trapping of Basic Lipophilic Compounds Using In Vitro Assays and In Silico Predictions Based on the Determination of the Full pH Profile of the Endo-/Lysosomal System in Rat Hepatocytes.
Drug Metab Dispos
; 47(1): 49-57, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30409837
6.
An international multicenter study comparing EUS-guided pancreatic duct drainage with enteroscopy-assisted endoscopic retrograde pancreatography after Whipple surgery.
Gastrointest Endosc
; 85(1): 170-177, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27460390
7.
Discovery of new selective glucocorticoid receptor agonist leads.
Bioorg Med Chem Lett
; 27(3): 437-442, 2017 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28043796
8.
Pharmacokinetics in Drug Discovery: An Exposure-Centred Approach to Optimising and Predicting Drug Efficacy and Safety.
Handb Exp Pharmacol
; 232: 235-60, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26330260
9.
Transplantation of human islets without immunosuppression.
Proc Natl Acad Sci U S A
; 110(47): 19054-8, 2013 Nov 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24167261
10.
Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist.
Proc Natl Acad Sci U S A
; 109(13): 5022-7, 2012 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-22393012
11.
Transforming the Discovery of Targeted Protein Degraders: The Translational Power of Predictive PK/PD Modeling.
Clin Pharmacol Ther
; 2024 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38708948
12.
A Mechanistic Pharmacodynamic Modeling Framework for the Assessment and Optimization of Proteolysis Targeting Chimeras (PROTACs).
Pharmaceutics
; 15(1)2023 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36678824
13.
Trends in Molecular Properties, Bioavailability, and Permeability across the Bayer Compound Collection.
J Med Chem
; 66(4): 2347-2360, 2023 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36752336
14.
Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
AAPS J
; 24(5): 85, 2022 07 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35854202
15.
Potential and Limits of Kidney Cells for Evaluation of Renal Excretion.
Pharmaceuticals (Basel)
; 14(9)2021 Sep 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34577608
16.
Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis.
Ann Rheum Dis
; 69(8): 1511-8, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20498199
17.
Clinical Recommendations for the Use of the Ambulatory Glucose Profile in Diabetes Care.
J Diabetes Sci Technol
; 14(3): 586-594, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31718268
18.
Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept.
Chem Biodivers
; 6(11): 2030-49, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19937839
19.
Quantitative molecular tissue atlas of Bis(monoacylglycero)phosphate and phosphatidylglycerol membrane lipids in rodent organs generated by methylation assisted high resolution mass spectrometry.
Anal Chim Acta
; 1084: 60-70, 2019 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31519235
20.
Characterization of cytochrome P450 protein expression along the entire length of the intestine of male and female rats.
Drug Metab Dispos
; 36(6): 1039-45, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18332081