Detalles de la búsqueda
1.
NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension.
BMC Pulm Med
; 20(1): 85, 2020 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32252727
2.
Differential expression of the TPα and TPß isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPß during monocyte-macrophage differentiation.
Exp Mol Pathol
; 110: 104277, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31271729
3.
Transcriptional regulation of the human thromboxane A2 receptor gene by Wilms' tumor (WT)1 and hypermethylated in cancer (HIC) 1 in prostate and breast cancers.
Biochim Biophys Acta
; 1839(6): 476-92, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24747176
4.
Prostacyclin receptors: Transcriptional regulation and novel signalling mechanisms.
Prostaglandins Other Lipid Mediat
; 121(Pt A): 70-82, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25936507
5.
Interaction of the human prostacyclin receptor with Rab11. Characterization of a novel Rab11 binding domain within α-helix 8 that is regulated by palmitoylation.
J Biol Chem
; 293(31): 12287, 2018 08 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30076259
6.
Identification of an interaction between the TPα and TPß isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1. Implications for prostate cancer.
J Biol Chem
; 293(31): 12286, 2018 08 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30076258
7.
Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP).
Biochim Biophys Acta
; 1823(10): 1998-2012, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22884631
8.
Evaluation of NTP42, a novel thromboxane receptor antagonist, in a first-in-human phase I clinical trial.
Front Pharmacol
; 14: 1296188, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38178863
9.
The α, but not the ß, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. INDEPENDENT MODULATION OF TPα SIGNALING BY NITRIC OXIDE AND PROSTACYCLIN.
J Biol Chem
; 291(37): 19260, 2016 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27613956
10.
Identification of an interaction between the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1: implications for prostate cancer.
J Biol Chem
; 286(17): 15440-57, 2011 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-21357687
11.
Identification of a novel endoplasmic reticulum export motif within the eighth α-helical domain (α-H8) of the human prostacyclin receptor.
Biochim Biophys Acta
; 1808(4): 1202-18, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21223948
12.
The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload.
Front Cardiovasc Med
; 9: 1063967, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36588576
13.
Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation.
J Biol Chem
; 285(24): 18709-26, 2010 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20395296
14.
Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension.
Eur J Pharmacol
; 889: 173658, 2020 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33121950
15.
Agonist-dependent internalization and trafficking of the human prostacyclin receptor: a direct role for Rab5a GTPase.
Biochim Biophys Acta
; 1783(10): 1914-28, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18498773
16.
Differential regulation of RhoA-mediated signaling by the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor: independent modulation of TPalpha signaling by prostacyclin and nitric oxide.
Cell Signal
; 20(8): 1497-512, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18502100
17.
Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling.
Biochim Biophys Acta
; 1773(6): 970-89, 2007 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-17466390
18.
Palmitoylation of the TPbeta isoform of the human thromboxane A2 receptor. Modulation of G protein: effector coupling and modes of receptor internalization.
Cell Signal
; 19(5): 1056-70, 2007 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-17229546
19.
Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension.
Cardiovasc Res
; 114(8): 1165-1177, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29584808
20.
IHG-1 increases mitochondrial fusion and bioenergetic function.
Diabetes
; 63(12): 4314-25, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25008184