Detalles de la búsqueda
1.
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature
; 575(7781): 217-223, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31666701
2.
Xenografted Tumors Share Comparable Fraction Unbound and Can Be Surrogated by Mouse Lung Tissue.
Drug Metab Dispos
; 2024 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38670798
3.
Structure guided design of a series of sphingosine kinase (SphK) inhibitors.
Bioorg Med Chem Lett
; 23(16): 4608-16, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23845219
4.
Rilotumumab Resistance Acquired by Intracrine Hepatocyte Growth Factor Signaling.
Cancers (Basel)
; 15(2)2023 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36672409
5.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg Med Chem Lett
; 22(12): 4089-93, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22595176
6.
Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors.
Clin Cancer Res
; 15(1): 110-8, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19118038
7.
Dual Inhibition of Angiopoietin-TIE2 and MET Alters the Tumor Microenvironment and Prolongs Survival in a Metastatic Model of Renal Cell Carcinoma.
Mol Cancer Ther
; 19(1): 147-156, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31582532
8.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31820981
9.
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
Bioorg Med Chem Lett
; 19(22): 6307-12, 2009 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19819693
10.
Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
J Med Chem
; 62(3): 1523-1540, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30624936
11.
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
J Med Chem
; 51(10): 2879-82, 2008 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-18426196
12.
AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts.
Clin Cancer Res
; 13(22 Pt 1): 6735-42, 2007 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18006775
13.
Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors.
Cancer Res
; 66(3): 1721-9, 2006 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16452232
14.
Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity.
Mol Cancer Res
; 15(11): 1587-1597, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28751462
15.
A protective role for keratinocyte growth factor in a murine model of chemotherapy and radiotherapy-induced mucositis.
Int J Radiat Oncol Biol Phys
; 66(1): 254-62, 2006 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16904525
16.
Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma.
Mol Cancer Ther
; 15(6): 1227-37, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27196749
17.
In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.
Mol Cancer Ther
; 15(7): 1568-79, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27196782
18.
Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
J Med Chem
; 59(6): 2328-42, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26812066
19.
Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.
ACS Med Chem Lett
; 7(4): 408-12, 2016 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27096050
20.
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.
J Med Chem
; 59(13): 6407-30, 2016 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27285051