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1.
Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells.
Mol Ther
; 30(3): 1171-1187, 2022 03 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35051615
2.
Bifunctional TGF-ß trap/IL-15 protein complex elicits potent NK cell and CD8+ T cell immunity against solid tumors.
Mol Ther
; 29(10): 2949-2962, 2021 10 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34091051
3.
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial.
Lancet Oncol
; 19(5): 694-704, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29628312
4.
Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models.
Cytokine
; 107: 105-112, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29452720
5.
A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses.
J Biol Chem
; 291(46): 23869-23881, 2016 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27650494
6.
Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model.
Int J Cancer
; 138(1): 187-94, 2016 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26174883
7.
A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice.
Front Immunol
; 14: 1114802, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36761778
8.
Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice.
Aging Cell
; 22(5): e13806, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36967480
9.
A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome.
BMC Pulm Med
; 12: 5, 2012 Feb 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-22340260
10.
IL-15:IL-15 receptor alpha superagonist complex: high-level co-expression in recombinant mammalian cells, purification and characterization.
Cytokine
; 56(3): 804-10, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22019703
11.
Novel human interleukin-15 agonists.
J Immunol
; 183(6): 3598-607, 2009 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19710453
12.
A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy.
Cancer Immunol Res
; 9(9): 1071-1087, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34244297
13.
Phase I Trial of ALT-803, A Novel Recombinant IL15 Complex, in Patients with Advanced Solid Tumors.
Clin Cancer Res
; 24(22): 5552-5561, 2018 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30045932
14.
Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models.
Cancer Immunol Res
; 4(1): 49-60, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26511282
15.
The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas.
Clin Cancer Res
; 22(3): 596-608, 2016 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26423796
16.
Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced bladder cancer rat model; a role for cytokine production and NK cell expansion.
PLoS One
; 9(6): e96705, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24896845
17.
The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8+ T cells into innate-like effector cells with antitumor activity.
Oncoimmunology
; 2(11): e26442, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24404427
18.
Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor αSu/Fc fusion complex in syngeneic murine models of multiple myeloma.
Cancer Res
; 73(10): 3075-86, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23644531
19.
Interleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune molecules.
Protein Eng Des Sel
; 24(4): 373-83, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21177283
20.
Phase I trial of ALT-801, an interleukin-2/T-cell receptor fusion protein targeting p53 (aa264-272)/HLA-A*0201 complex, in patients with advanced malignancies.
Clin Cancer Res
; 17(24): 7765-75, 2011 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21994418