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1.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Prediction of Monoclonal Antibody Tumor Disposition.
Int J Mol Sci
; 23(2)2022 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35054865
2.
Nonclinical Development of Biologics: Integrating Safety, Pharmacokinetics, and Pharmacodynamics to Create Smarter and More Flexible Nonclinical Safety Programs Optimizing Animal Use.
Int J Toxicol
; 40(3): 270-284, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33631988
3.
High-Throughput, Sensitive LC-MS Quantification of Biotherapeutics and Biomarkers Using Antibody-Free, Peptide-Level, Multiple-Mechanism Enrichment via Strategic Regulation of pH and Ionic and Solvent Strengths.
Anal Chem
; 91(5): 3475-3483, 2019 03 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30712341
4.
Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.
Drug Metab Dispos
; 47(12): 1443-1456, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31748266
5.
Prediction of Human Pharmacokinetics of Fomepizole from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles.
AAPS PharmSciTech
; 20(6): 221, 2019 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-31214899
6.
Synthesis of a tubugi-1-toxin conjugate by a modulizable disulfide linker system with a neuropeptide Y analogue showing selectivity for hY1R-overexpressing tumor cells.
Beilstein J Org Chem
; 15: 96-105, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30680044
7.
Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing.
Regul Toxicol Pharmacol
; 94: 91-100, 2018 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-29355662
8.
LC-ESI-MS/MS determination of 4-methylpyrazole in dog plasma and its application to a pharmacokinetic study in dogs.
Biomed Chromatogr
; 32(2)2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28810079
9.
Intramedullary nailing in opening wedge high tibial osteotomy-in vitro test for validation of a method of fixation.
Int Orthop
; 42(8): 1835-1843, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29392383
10.
In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.
Anal Chem
; 88(23): 11670-11677, 2016 12 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27934109
11.
Non-clinical Safety Evaluation of Biotherapeutics - Challenges, Opportunities and new Insights.
Regul Toxicol Pharmacol
; 80S: S1-S14, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-27578450
12.
Subcutaneous absorption of biotherapeutics: knowns and unknowns.
Drug Metab Dispos
; 42(11): 1881-9, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25100673
13.
New challenges and opportunities in nonclinical safety testing of biologics.
Regul Toxicol Pharmacol
; 69(2): 226-33, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24755365
14.
Effects of feeding diets containing increasing proportions of bunt-infected wheat (Tilletia caries) on performance and health of pigs.
Arch Anim Nutr
; 68(1): 55-62, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24499404
15.
The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.
Birth Defects Res B Dev Reprod Toxicol
; 98(2): 170-82, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23529913
16.
Click Chemistry-Generated Auristatin F-Linker-Benzylguanine for a SNAP-Tag-Based Recombinant Antibody-Drug Conjugate Demonstrating Selective Cytotoxicity toward EGFR-Overexpressing Tumor Cells.
ACS Omega
; 8(4): 4026-4037, 2023 Jan 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-36743041
17.
CSPG4 as a target for the specific killing of triple-negative breast cancer cells by a recombinant SNAP-tag-based antibody-auristatin F drug conjugate.
J Cancer Res Clin Oncol
; 149(13): 12203-12225, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37432459
18.
Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper.
MAbs
; 14(1): 2145997, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36418217
19.
Novel in Vivo and in Vitro Pharmacokinetic/Pharmacodynamic-Based Human Starting Dose Selection for Glofitamab.
J Pharm Sci
; 111(4): 1208-1218, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-34953862
20.
Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential.
Cell Chem Biol
; 29(4): 586-596.e4, 2022 04 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34699747