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1.
Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived ß 2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies.
J Pharmacol Exp Ther
; 369(2): 188-199, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30819762
2.
Small-molecule WNK inhibition regulates cardiovascular and renal function.
Nat Chem Biol
; 12(11): 896-898, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27595330
3.
Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach.
J Pharmacol Exp Ther
; 360(2): 356-367, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27934627
4.
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.
Bioorg Med Chem Lett
; 25(8): 1787-1791, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25754490
5.
Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects.
J Transl Med
; 12: 340, 2014 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25491597
6.
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone.
J Pharmacol Exp Ther
; 334(1): 232-43, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20354176
7.
The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.
Bioorg Med Chem Lett
; 20(15): 4324-7, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20615692
8.
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
ACS Med Chem Lett
; 11(2): 188-194, 2020 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32071687
9.
Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation.
Eur J Pharm Sci
; 128: 103-111, 2019 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30508581
10.
Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma.
J Med Chem
; 60(20): 8466-8481, 2017 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29035537
11.
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
J Med Chem
; 60(16): 7099-7107, 2017 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-28771350
12.
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
J Med Chem
; 58(11): 4749-70, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25953419
13.
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
J Med Chem
; 58(23): 9382-94, 2015 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26540564
14.
Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.
ACS Med Chem Lett
; 5(7): 787-92, 2014 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25050166
15.
Chronic measurement of left ventricular pressure in freely moving rats.
J Appl Physiol (1985)
; 115(11): 1672-82, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24114699
16.
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.
J Med Chem
; 56(6): 2207-17, 2013 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23425156
17.
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
J Med Chem
; 56(6): 2196-206, 2013 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23360239
18.
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
ACS Med Chem Lett
; 4(12): 1203-7, 2013 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900631
19.
Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).
J Clin Pharmacol
; 50(4): 401-14, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19934029
20.
Echocardiographic examination in rats and mice.
Methods Mol Biol
; 573: 139-55, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19763926
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