Detalles de la búsqueda
1.
The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development.
Arch Toxicol
; 94(8): 2559-2585, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32372214
2.
Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1.
Drug Metab Dispos
; 47(1): 1-8, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30348903
3.
Development and Characterization of a Human Hepatocyte Low Intrinsic Clearance Assay for Use in Drug Discovery.
Drug Metab Dispos
; 46(8): 1169-1178, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29880630
4.
Application of an in vitro OAT assay in drug design and optimization of renal clearance.
Xenobiotica
; 44(7): 657-65, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24417751
5.
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.
Drug Metab Dispos
; 40(8): 1641-8, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22587986
6.
The discovery of CCR3/H1 dual antagonists with reduced hERG risk.
Bioorg Med Chem Lett
; 22(21): 6688-93, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23031591
7.
Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.
Bioorg Med Chem Lett
; 22(21): 6694-9, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23021991
8.
Studying the right transporter at the right time: an in vitro strategy for assessing drug-drug interaction risk during drug discovery and development.
Expert Opin Drug Metab Toxicol
; 18(10): 619-655, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-36205497
9.
Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption.
Drug Metab Dispos
; 39(6): 1008-13, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21357702
10.
Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells.
Drug Metab Dispos
; 37(6): 1259-68, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19307295
11.
Impact of hepatic uptake transporters on pharmacokinetics and drug-drug interactions: use of assays and models for decision making in the pharmaceutical industry.
Mol Pharm
; 6(6): 1662-77, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19402709
12.
Estimating human ADME properties, pharmacokinetic parameters and likely clinical dose in drug discovery.
Expert Opin Drug Discov
; 14(12): 1313-1327, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31538500
13.
Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes.
Drug Metab Dispos
; 36(8): 1670-8, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18474678
14.
Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions.
Drug Metab Dispos
; 36(6): 1126-34, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18356267
15.
Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes.
Drug Metab Dispos
; 36(7): 1365-74, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18426955
16.
Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.
J Med Chem
; 50(24): 5882-5, 2007 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17963373
17.
The pivotal role of hepatocytes in drug discovery.
Chem Biol Interact
; 168(1): 2-15, 2007 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-17208208
18.
Time-dependent CYP inhibition.
Expert Opin Drug Metab Toxicol
; 3(1): 51-66, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17269894
19.
Hepatic transporter drug-drug interactions: an evaluation of approaches and methodologies.
Expert Opin Drug Metab Toxicol
; 13(12): 1237-1250, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29121476
20.
Harmonised high throughput microsomal stability assay.
J Pharmacol Toxicol Methods
; 84: 31-36, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27773845