Detalles de la búsqueda
1.
Bromodomain and extra-terminal domain inhibition modulates the expression of pathologically relevant microRNAs in diffuse large B-cell lymphoma.
Haematologica
; 103(12): 2049-2058, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30076183
2.
OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models.
Int J Cancer
; 139(9): 2047-55, 2016 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27388964
3.
Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action.
Bioorg Med Chem
; 20(18): 5537-49, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22925447
4.
Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.
Eur J Med Chem
; 226: 113895, 2021 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34624821
5.
Role of the Tyrosine Phosphatase SHP-2 in Mediating Adrenomedullin Proangiogenic Activity in Solid Tumors.
Front Oncol
; 11: 753244, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34692535
6.
Targeting Adrenomedullin in Oncology: A Feasible Strategy With Potential as Much More Than an Alternative Anti-Angiogenic Therapy.
Front Oncol
; 10: 589218, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33489885
7.
Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells.
Bioorg Med Chem
; 17(18): 6547-59, 2009 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19716307
8.
Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer.
Cell Metab
; 30(2): 303-318.e6, 2019 08 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31130467
9.
Biochemical mechanisms underlying the pro-apoptotic activity of 7,8-dihydroxy-4-methylcoumarin in human leukemic cells.
Biochem Pharmacol
; 75(3): 725-36, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17996847
10.
Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells.
Bioorg Med Chem
; 16(5): 2665-75, 2008 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18060791
11.
BET bromodomain inhibitor birabresib in mantle cell lymphoma: in vivo activity and identification of novel combinations to overcome adaptive resistance.
ESMO Open
; 3(6): e000387, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30305939
12.
The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus.
Oncotarget
; 8(5): 7598-7613, 2017 Jan 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-27935867
13.
OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations.
Oncotarget
; 7(51): 84675-84687, 2016 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-27835869
14.
Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes.
Oncotarget
; 7(48): 79637-79653, 2016 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-27793034
15.
Phase I Population Pharmacokinetic Assessment of the Oral Bromodomain Inhibitor OTX015 in Patients with Haematologic Malignancies.
Clin Pharmacokinet
; 55(3): 397-405, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26341814
16.
Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.
Clin Cancer Res
; 22(10): 2470-81, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26631615
17.
Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors.
Biochimie
; 108: 101-7, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25446656
18.
BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells.
Oncotarget
; 6(19): 17698-712, 2015 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25989842
19.
Insights on the CXCL12-CXCR4 axis in hepatocellular carcinoma carcinogenesis.
Am J Transl Res
; 6(4): 340-52, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25075251
20.
Unraveling galectin-1 as a novel therapeutic target for cancer.
Cancer Treat Rev
; 40(2): 307-19, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23953240