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1.
Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg Med Chem
; 100: 117614, 2024 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38340640
2.
Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells.
Cell Commun Signal
; 20(1): 99, 2022 06 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35761398
3.
Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells.
Cell Commun Signal
; 19(1): 97, 2021 09 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-34563224
4.
Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice.
Int J Mol Sci
; 22(14)2021 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34299083
5.
A Novel Dual Drug Approach That Combines Ivermectin and Dihydromyricetin (DHM) to Reduce Alcohol Drinking and Preference in Mice.
Molecules
; 26(6)2021 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33810134
6.
A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens.
Antibiotics (Basel)
; 13(3)2024 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38534644
7.
Fragment Screening to Identify Inhibitors Targeting Ribosome Binding of Shiga Toxin 2.
ACS Infect Dis
; 2024 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38873918
8.
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
J Med Chem
; 67(5): 3467-3503, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38372781
9.
Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency.
ACS Omega
; 8(7): 6597-6607, 2023 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36844602
10.
Ym155 localizes to the mitochondria leading to mitochondria dysfunction and activation of AMPK that inhibits BMP signaling in lung cancer cells.
Sci Rep
; 12(1): 13135, 2022 07 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35908087
11.
TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens.
Antibiotics (Basel)
; 11(5)2022 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35625337
12.
Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans.
Cell Biosci
; 12(1): 76, 2022 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35641992
13.
The Anticancer Drug Bleomycin Shows Potent Antifungal Activity by Altering Phospholipid Biosynthesis.
Microbiol Spectr
; 10(5): e0086222, 2022 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36036637
14.
EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.
Pharmacol Res
; 63(4): 284-93, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21215314
15.
C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem Lett
; 21(15): 4465-70, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21737266
16.
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
J Med Chem
; 64(4): 2024-2045, 2021 02 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33538587
17.
Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.
J Med Chem
; 64(20): 15334-15348, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34648707
18.
Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.
J Comb Chem
; 11(1): 72-82, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19086798
19.
Characterization of a new class of selective nonsteroidal progesterone receptor agonists.
Steroids
; 69(3): 201-17, 2004 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-15072922
20.
Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 57(4): 1236-51, 2014 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24456245