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1.
Cerebrospinal fluid ß-Amyloid turnover in the mouse, dog, monkey and human evaluated by systematic quantitative analyses.
Neurodegener Dis
; 12(1): 36-50, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-22922480
2.
Cerebrospinal fluid amyloid-ß (Aß) as an effect biomarker for brain Aß lowering verified by quantitative preclinical analyses.
J Pharmacol Exp Ther
; 342(2): 366-75, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22562771
3.
Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors.
J Pharmacol Exp Ther
; 339(3): 922-34, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21930801
4.
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
J Med Chem
; 61(10): 4476-4504, 2018 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29613789
5.
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J Med Chem
; 60(1): 386-402, 2017 01 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27997172
6.
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
J Med Chem
; 58(6): 2678-702, 2015 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25695670
7.
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.
J Med Chem
; 58(7): 3223-52, 2015 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25781223
8.
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
J Med Chem
; 55(7): 3414-24, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22420884
9.
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.
J Med Chem
; 54(22): 7772-83, 2011 Nov 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21995460
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