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1.
Aß43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation.
EMBO Rep
; 21(1): e47996, 2020 01 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31762188
2.
Novel ß-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.
Angew Chem Int Ed Engl
; 60(10): 5436-5442, 2021 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33238058
3.
Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere.
J Med Chem
; 63(15): 8534-8553, 2020 08 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32706964
4.
Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease.
ACS Med Chem Lett
; 11(6): 1257-1268, 2020 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32551009
5.
Selective naphthalene H(3) receptor inverse agonists with reduced potential to induce phospholipidosis and their quinoline analogs.
Bioorg Med Chem Lett
; 19(15): 4495-500, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19524437
6.
Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.
Nat Commun
; 8(1): 1206, 2017 10 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-29089518
7.
Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket.
J Med Chem
; 59(22): 10163-10175, 2016 11 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27685665
8.
Correction to Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket.
J Med Chem
; 60(9): 4099, 2017 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28448141
9.
5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.
J Med Chem
; 52(13): 3855-68, 2009 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-19456097
10.
A new class of histamine H3 receptor antagonists derived from ligand based design.
Bioorg Med Chem Lett
; 17(13): 3670-5, 2007 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17498953
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