Detalles de la búsqueda
1.
Safety and Efficacy of Efruxifermin in Combination With a GLP-1 Receptor Agonist in Patients With NASH/MASH and Type 2 Diabetes in a Randomized Phase 2 Study.
Clin Gastroenterol Hepatol
; 2024 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38447814
2.
Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates.
Diabetes Obes Metab
; 19(12): 1762-1772, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28573777
3.
Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy.
J Am Soc Nephrol
; 27(11): 3459-3468, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27113485
4.
Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.
Diabetologia
; 58(10): 2324-35, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26254576
5.
A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis.
JHEP Rep
; 5(1): 100563, 2023 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-36644237
6.
Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin.
J Pharm Biomed Anal
; 232: 115402, 2023 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37141854
7.
Safety and efficacy of once-weekly efruxifermin versus placebo in non-alcoholic steatohepatitis (HARMONY): a multicentre, randomised, double-blind, placebo-controlled, phase 2b trial.
Lancet Gastroenterol Hepatol
; 8(12): 1080-1093, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37802088
8.
Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial.
Nat Med
; 27(7): 1262-1271, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34239138
9.
Fibroblast growth factor (FGF)-21 based therapies: A magic bullet for nonalcoholic fatty liver disease (NAFLD)?
Expert Opin Investig Drugs
; 29(2): 197-204, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-31948295
10.
Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
Cell Rep
; 33(6): 108375, 2020 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33176135
11.
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Sci Transl Med
; 11(492)2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31092695
12.
The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.
Cell Rep
; 14(2): 243-54, 2016 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-26748706
13.
Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.
Mol Metab
; 5(7): 538-551, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27408778
14.
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.
Cell Metab
; 23(3): 427-40, 2016 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26959184
15.
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.
J Med Chem
; 59(3): 1165-75, 2016 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26734723
16.
Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.
ACS Chem Biol
; 11(9): 2529-40, 2016 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27391855
17.
Do ENSO and Coastal Development Enhance Coastal Burial of Terrestrial Carbon?
PLoS One
; 10(12): e0145136, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26691557
18.
FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance.
Sci Rep
; 5: 11382, 2015 Jul 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26153793
19.
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).
Sci Rep
; 5: 17391, 2015 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26620127
20.
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional ß cells.
J Clin Invest
; 125(10): 3847-60, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26389676