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1.
Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates.
Diabetes Obes Metab
; 19(12): 1762-1772, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28573777
2.
Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.
Diabetologia
; 58(10): 2324-35, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26254576
3.
Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin.
J Pharm Biomed Anal
; 232: 115402, 2023 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37141854
4.
Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial.
Nat Med
; 27(7): 1262-1271, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34239138
5.
Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
Cell Rep
; 33(6): 108375, 2020 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33176135
6.
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Sci Transl Med
; 11(492)2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31092695
7.
The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.
Cell Rep
; 14(2): 243-54, 2016 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-26748706
8.
Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.
Mol Metab
; 5(7): 538-551, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27408778
9.
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.
Cell Metab
; 23(3): 427-40, 2016 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26959184
10.
Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.
ACS Chem Biol
; 11(9): 2529-40, 2016 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27391855
11.
FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance.
Sci Rep
; 5: 11382, 2015 Jul 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26153793
12.
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional ß cells.
J Clin Invest
; 125(10): 3847-60, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26389676
13.
The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.
PLoS One
; 9(5): e97139, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24858947
14.
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
J Med Chem
; 55(3): 1318-33, 2012 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-22196621
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