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1.
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Nat Cancer
; 2(10): 1002-1017, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34790902
2.
Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.
ACS Med Chem Lett
; 4(10): 964-8, 2013 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900593
3.
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.
ACS Med Chem Lett
; 3(12): 1091-6, 2012 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900432
4.
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).
J Med Chem
; 55(16): 7193-207, 2012 Aug 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-22827572
5.
Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
J Med Chem
; 54(6): 1871-95, 2011 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21341675
6.
On the mechanism of the palladium(II)-catalyzed decarboxylative olefination of arene carboxylic acids. Crystallographic characterization of non-phosphine palladium(II) intermediates and observation of their stepwise transformation in Heck-like processes.
J Am Chem Soc
; 127(29): 10323-33, 2005 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-16028944
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