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1.
Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature
; 626(7997): 194-206, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38096902
2.
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Proc Natl Acad Sci U S A
; 119(27): e2200260119, 2022 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35771941
3.
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis.
Bioorg Med Chem Lett
; 73: 128891, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35842205
4.
Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field.
J Am Chem Soc
; 137(7): 2695-703, 2015 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-25625324
5.
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
J Med Chem
; 66(15): 10473-10496, 2023 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37427891
6.
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
J Med Chem
; 62(10): 4884-4901, 2019 05 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31013090
7.
Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: evidence for disruption of cell wall biosynthesis.
J Antimicrob Chemother
; 62(4): 720-9, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-18567575
8.
Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics.
Bioorg Med Chem Lett
; 18(23): 6293-7, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18951783
9.
Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders.
J Med Chem
; 58(1): 96-110, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25479567
10.
Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy.
J Exp Med
; 212(13): 2189-201, 2015 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26621451
11.
Asymmetric Synthesis of the C3alpha Fragment of 5,6-Dihydro-alpha-pyrone Nonpeptidic HIV-1 Protease Inhibitors.
J Org Chem
; 64(13): 4980-4984, 1999 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-11674587
12.
Current HIV therapeutics: mechanistic and chemical determinants of toxicity.
Curr Opin Drug Discov Devel
; 12(1): 53-60, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19152213
13.
Human serum albumin binding assay based on displacement of a non selective fluorescent inhibitor.
Bioorg Med Chem Lett
; 17(16): 4646-9, 2007 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17560104
14.
Preparation of novel anthranilic acids as antibacterial agents: extensive evaluation of structural and physical properties on antibacterial activity and human serum albumin affinity.
Bioorg Med Chem Lett
; 17(11): 3113-6, 2007 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17400450
15.
Correlation of carboxylic acid pKa to protein binding and antibacterial activity of a novel class of bacterial translation inhibitors.
Bioorg Med Chem Lett
; 17(19): 5479-82, 2007 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17709248
16.
Structure-activity relationships of bioisosteres of a carboxylic acid in a novel class of bacterial translation inhibitors.
Bioorg Med Chem Lett
; 17(14): 4040-3, 2007 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17561394
17.
Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles.
Bioorg Med Chem Lett
; 17(8): 2347-50, 2007 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17350254
18.
Preparation of novel anthranilic acids as antibacterial agents. Extensive evaluation of alternative amide bioisosteres connecting the A- and the B-rings.
Bioorg Med Chem Lett
; 17(10): 2823-7, 2007 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17368020
19.
Discovery and initial development of a novel class of antibacterials: inhibitors of Staphylococcus aureus transcription/translation.
Bioorg Med Chem Lett
; 16(24): 6173-7, 2006 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17027262
20.
A stereoselective intramolecular 1,3-dipolar nitrone cycloaddition for the synthesis of substituted chromanes.
J Org Chem
; 67(10): 3317-22, 2002 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-12003541
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