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1.
Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse.
Drug Metab Dispos
; 44(8): 1213-6, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27271368
2.
A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice.
Drug Metab Dispos
; 42(1): 70-7, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24115751
3.
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
Drug Metab Dispos
; 41(1): 12-23, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23086197
4.
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.
Bioorg Med Chem
; 20(5): 1779-93, 2012 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22304848
5.
Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma.
J Immunother Cancer
; 10(5)2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35606087
6.
Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.
Cancer Discov
; 12(3): 812-835, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34848557
7.
The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s.
Drug Metab Dispos
; 39(8): 1423-32, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21555506
8.
Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
J Med Chem
; 64(14): 10333-10349, 2021 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34196551
9.
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ß-thalassemia mouse model.
J Clin Invest
; 131(10)2021 05 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33822774
10.
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia.
J Exp Med
; 218(5)2021 05 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33760042
11.
Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism.
Mol Pharmacol
; 78(2): 269-78, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20430864
12.
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
Mol Cancer Ther
; 19(12): 2502-2515, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33082276
13.
Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia.
Leukemia
; 36(3): 869-872, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34743189
14.
Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.
J Biol Chem
; 283(46): 31385-93, 2008 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-18805792
15.
Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen.
Cell Cycle
; 7(21): 3417-27, 2008 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18971638
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