Detalles de la búsqueda
1.
A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.
Int J Toxicol
; 38(1): 23-32, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30567462
2.
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute.
J Pharmacol Toxicol Methods
; 121: 107265, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36997076
3.
CardioMotion: identification of functional and structural cardiotoxic liabilities in small molecules through brightfield kinetic imaging.
Toxicol Sci
; 195(1): 61-70, 2023 08 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-37462734
4.
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
J Pharmacol Toxicol Methods
; 123: 107270, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37164235
5.
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis.
J Pharmacol Toxicol Methods
; 121: 107266, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36963703
6.
A novel cardiovascular systems model to quantify drugs effects on the inter-relationship between contractility and other hemodynamic variables.
CPT Pharmacometrics Syst Pharmacol
; 11(5): 640-652, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35213797
7.
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19.
Clin Transl Sci
; 14(3): 1133-1146, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33620150
8.
Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation.
J Pharmacol Toxicol Methods
; 105: 106897, 2020 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-32663523
9.
Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes.
Toxicol Sci
; 176(1): 103-123, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32421822
10.
The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model.
J Pharmacol Exp Ther
; 329(3): 1127-33, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19252062
11.
Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents.
Bioorg Med Chem Lett
; 19(16): 4551-4, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616941
12.
GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs.
J Cardiovasc Pharmacol Ther
; 14(3): 207-14, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19721133
13.
mproving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment.
J Pharmacol Toxicol Methods
; : 107515, 2024 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38777240
14.
Impaired contractile reserve in severe mitral valve regurgitation with a preserved ejection fraction.
Eur J Heart Fail
; 9(9): 857-64, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17594913
15.
An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs.
J Pharmacol Toxicol Methods
; 85: 1-21, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28065821
16.
Evaluation of a method utilizing PhysioFlow®, a novel signal morphology-based form of impedance cardiography, to measure cardiac output in the conscious beagle.
J Pharmacol Toxicol Methods
; 81: 115-9, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27050559
17.
Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart.
J Am Coll Cardiol
; 44(4): 837-45, 2004 Aug 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15312868
18.
The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium.
J Pharmacol Toxicol Methods
; 75: 70-90, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25843226
19.
Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs.
Circ Arrhythm Electrophysiol
; 2(2): 171-8, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19808462
20.
Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation.
J Med Chem
; 52(4): 908-11, 2009 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-19175320