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1.

A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab.

Mathieu, Chantal; Wiedeman, Alice; Cerosaletti, Karen; Long, S Alice; Serti, Elisavet; Cooney, Laura; Vermeiren, Joan; Caluwaerts, Silvia; Van Huynegem, Karolien; Steidler, Lothar; Blomme, Sven; Rottiers, Pieter; Nepom, Gerald T; Herold, Kevan C.

Diabetologia ; 67(1): 27-41, 2024 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-37782353

2.

A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis-Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes.

Sassi, Gabriele; Licata, Giada; Ventriglia, Giuliana; Wouters, Amber; Lemaitre, Pierre; Seurinck, Ruth; Mori, Alessia; Grieco, Giuseppina Emanuela; Bissenova, Samal; Ellis, Darcy; Caluwaerts, Silvia; Rottiers, Pieter; Vandamme, Niels; Mathieu, Chantal; Dotta, Francesco; Gysemans, Conny; Sebastiani, Guido.

Diabetes ; 72(10): 1470-1482, 2023 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-37494666

3.

Induction of antigen-specific tolerance by oral administration of Lactococcus lactis delivered immunodominant DQ8-restricted gliadin peptide in sensitized nonobese diabetic Abo Dq8 transgenic mice.

Huibregtse, Inge L; Marietta, Eric V; Rashtak, Shadi; Koning, Frits; Rottiers, Pieter; David, Chella S; van Deventer, Sander J H; Murray, Joseph A.

J Immunol ; 183(4): 2390-6, 2009 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-19635921

4.

Intestinal Delivery of Proinsulin and IL-10 via Lactococcus lactis Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis.

Cook, Dana P; Cunha, João Paulo Monteiro Carvalho Mori; Martens, Pieter-Jan; Sassi, Gabriele; Mancarella, Francesca; Ventriglia, Giuliana; Sebastiani, Guido; Vanherwegen, An-Sofie; Atkinson, Mark A; Van Huynegem, Karolien; Steidler, Lothar; Caluwaerts, Silvia; Rottiers, Pieter; Teyton, Luc; Dotta, Francesco; Gysemans, Conny; Mathieu, Chantal.

Front Immunol ; 11: 1103, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-32582188

5.

Expression of galectins-1, -3 and -4 varies with strain and type of experimental colitis in mice.

Mathieu, Anne; Nagy, Nathalie; Decaestecker, Christine; Ferdinande, Liesbeth; Vandenbroucke, Klaas; Rottiers, Pieter; Cuvelier, Claude A; Salmon, Isabelle; Demetter, Pieter.

Int J Exp Pathol ; 89(6): 438-46, 2008 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-19134053

6.

Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice.

Waeytens, Anouk; Ferdinande, Liesbeth; Neirynck, Sabine; Rottiers, Pieter; De Vos, Martine; Steidler, Lothar; Cuvelier, Claude A.

Inflamm Bowel Dis ; 14(4): 471-9, 2008 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-18092343

7.

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10-Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells.

Takiishi, Tatiana; Cook, Dana Paulina; Korf, Hannelie; Sebastiani, Guido; Mancarella, Francesca; Cunha, João Paulo Monteiro Carvalho Mori; Wasserfall, Clive; Casares, Noelia; Lasarte, Juan José; Steidler, Lothar; Rottiers, Pieter; Dotta, Francesco; Gysemans, Conny; Mathieu, Chantal.

Diabetes ; 66(2): 448-459, 2017 02.

Artículo en Inglés | MEDLINE | ID: mdl-28108611

8.

Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy.

Heirman, Ingeborg; Ginneberge, Daisy; Brigelius-Flohé, Regina; Hendrickx, Nico; Agostinis, Patrizia; Brouckaert, Peter; Rottiers, Pieter; Grooten, Johan.

Free Radic Biol Med ; 40(2): 285-94, 2006 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-16413410

9.

Therapeutic drug delivery by genetically modified Lactococcus lactis.

Steidler, Lothar; Rottiers, Pieter.

Ann N Y Acad Sci ; 1072: 176-86, 2006 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-17057198

10.

Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma.

Van Gele, Mireille; Boyle, Glen M; Cook, Anthony L; Vandesompele, Jo; Boonefaes, Tom; Rottiers, Pieter; Van Roy, Nadine; De Paepe, Anne; Parsons, Peter G; Leonard, J Helen; Speleman, Frank.

Oncogene ; 23(15): 2732-42, 2004 Apr 08.

Artículo en Inglés | MEDLINE | ID: mdl-14755241

11.

Development of an enteric-coated, layered multi-particulate formulation for ileal delivery of viable recombinant Lactococcus lactis.

Huyghebaert, Nathalie; Vermeire, An; Rottiers, Pieter; Remaut, Erik; Remon, Jean Paul.

Eur J Pharm Biopharm ; 61(3): 134-41, 2005 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-15967652

12.

Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice.

Robert, Sofie; Gysemans, Conny; Takiishi, Tatiana; Korf, Hannelie; Spagnuolo, Isabella; Sebastiani, Guido; Van Huynegem, Karolien; Steidler, Lothar; Caluwaerts, Silvia; Demetter, Pieter; Wasserfall, Clive H; Atkinson, Mark A; Dotta, Francesco; Rottiers, Pieter; Van Belle, Tom L; Mathieu, Chantal.

Diabetes ; 63(8): 2876-87, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-24677716

13.

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.

Takiishi, Tatiana; Korf, Hannelie; Van Belle, Tom L; Robert, Sofie; Grieco, Fabio A; Caluwaerts, Silvia; Galleri, Letizia; Spagnuolo, Isabella; Steidler, Lothar; Van Huynegem, Karolien; Demetter, Pieter; Wasserfall, Clive; Atkinson, Mark A; Dotta, Francesco; Rottiers, Pieter; Gysemans, Conny; Mathieu, Chantal.

J Clin Invest ; 122(5): 1717-25, 2012 May.

Artículo en Inglés | MEDLINE | ID: mdl-22484814

14.

AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis.

Caluwaerts, Silvia; Vandenbroucke, Klaas; Steidler, Lothar; Neirynck, Sabine; Vanhoenacker, Peter; Corveleyn, Sam; Watkins, Brynmor; Sonis, Stephen; Coulie, Bernard; Rottiers, Pieter.

Oral Oncol ; 46(7): 564-70, 2010 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-20542722

15.

Actobiotics as a novel method for cytokine delivery.

Steidler, Lothar; Rottiers, Pieter; Coulie, Bernard.

Ann N Y Acad Sci ; 1182: 135-45, 2009 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-20074282

16.

Modulation of gut-associated lymphoid tissue functions with genetically modified Lactococcus lactis.

Rottiers, Pieter; De Smedt, Tim; Steidler, Lothar.

Int Rev Immunol ; 28(6): 465-86, 2009.

Artículo en Inglés | MEDLINE | ID: mdl-19954359

17.

Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin.

Huibregtse, Inge L; Snoeck, Veerle; de Creus, An; Braat, Henri; De Jong, Ester C; Van Deventer, Sander J H; Rottiers, Pieter.

Gastroenterology ; 133(2): 517-28, 2007 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-17681173

18.

A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner.

Coppieters, Ken; Van Beneden, Katrien; Jacques, Peggy; Dewint, Pieter; Vervloet, Ann; Vander Cruyssen, Bert; Van Calenbergh, Serge; Chen, Guangwu; Franck, Richard W; Verbruggen, Gust; Deforce, Dieter; Matthys, Patrick; Tsuji, Moriya; Rottiers, Pieter; Elewaut, Dirk.

J Immunol ; 179(4): 2300-9, 2007 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-17675491

19.

Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance.

Termont, Sofie; Vandenbroucke, Klaas; Iserentant, Dirk; Neirynck, Sabine; Steidler, Lothar; Remaut, Erik; Rottiers, Pieter.

Appl Environ Microbiol ; 72(12): 7694-700, 2006 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-17028239

20.

A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease.

Braat, Henri; Rottiers, Pieter; Hommes, Daniel W; Huyghebaert, Nathalie; Remaut, Erik; Remon, Jean-Paul; van Deventer, Sander J H; Neirynck, Sabine; Peppelenbosch, Maikel P; Steidler, Lothar.

Clin Gastroenterol Hepatol ; 4(6): 754-9, 2006 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-16716759

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