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1.
Tumor Distribution by Quantitative Mass Spectrometry Imaging of the Inhibitor of Apoptosis Protein Antagonist Xevinapant in Patients with Resectable Squamous Cell Carcinoma of the Head and Neck (EudraCT Number: 2014-004655-31).
Anal Chem
; 94(36): 12333-12341, 2022 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36040476
2.
Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study.
Lancet Oncol
; 21(9): 1173-1187, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32758455
3.
Model-Informed Selection of the Recommended Phase III Dose of the Inhibitor of Apoptosis Protein Inhibitor, Xevinapant, in Combination with Cisplatin and Concurrent Radiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck.
Clin Pharmacol Ther
; 115(1): 52-61, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37777832
4.
Exploratory window-of-opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer.
Clin Transl Sci
; 15(1): 55-62, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33742767
5.
Phase I Trial of Debio 1143, an Antagonist of Inhibitor of Apoptosis Proteins, Combined with Cisplatin Chemoradiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck.
Clin Cancer Res
; 26(24): 6429-6436, 2020 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32994295
6.
Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients.
Clin Cancer Res
; 10(15): 5151-9, 2004 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15297419
7.
Oral Debio1143 (AT406), an antagonist of inhibitor of apoptosis proteins, combined with daunorubicin and cytarabine in patients with poor-risk acute myeloid leukemia--results of a phase I dose-escalation study.
Clin Lymphoma Myeloma Leuk
; 15(7): 443-9, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25842225
8.
Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study.
Cancer Chemother Pharmacol
; 75(4): 851-9, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25716544
9.
Brivaracetam single and multiple rising oral dose study in healthy Japanese participants: influence of CYP2C19 genotype.
Drug Metab Pharmacokinet
; 29(5): 394-9, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24717838
10.
Pharmacokinetics of levetiracetam XR 500mg tablets.
Epilepsy Res
; 84(2-3): 224-31, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19264451
11.
Non-linear pharmacokinetics of irinotecan in mice.
Anticancer Drugs
; 13(6): 631-5, 2002 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-12172509
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