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1.
Effect of Early Treatment with Ivermectin among Patients with Covid-19.
N Engl J Med
; 386(18): 1721-1731, 2022 05 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35353979
2.
Use of Developmental Midazolam and 1-Hydroxymidazolam Data with Pediatric Physiologically Based Modeling to Assess Cytochrome P450 3A4 and Uridine Diphosphate Glucuronosyl Transferase 2B4 Ontogeny In Vivo.
Drug Metab Dispos
; 51(8): 1035-1045, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37169511
3.
The absorption kinetics of ketoconazole plays a major role in explaining the reported variability in the level of interaction with midazolam: Interplay between formulation and inhibition of gut wall and liver metabolism.
Biopharm Drug Dispos
; 38(3): 260-270, 2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28004396
4.
How Does In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach.
Drug Metab Dispos
; 44(7): 1090-8, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26862026
5.
Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model.
Drug Metab Dispos
; 44(6): 821-32, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27026679
6.
Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib.
Clin Pharmacol Ther
; 115(2): 299-308, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37971208
7.
Dose Optimization Informed by PBPK Modeling: State-of-the Art and Future.
Clin Pharmacol Ther
; 2024 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38686708
8.
Advancing the utilization of real-world data and real-world evidence in clinical pharmacology and translational research-Proceedings from the ASCPT 2023 preconference workshop.
Clin Transl Sci
; 17(4): e13785, 2024 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38572980
9.
Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans.
Xenobiotica
; 43(12): 1027-36, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23641955
10.
PBPK modeling of ivermectin-Considerations for the purpose of developing alternative routes to optimize its safety profile.
CPT Pharmacometrics Syst Pharmacol
; 12(5): 598-609, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36840414
11.
Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants.
Clin Pharmacol Ther
; 114(1): 182-191, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37078251
12.
Another Step Toward Qualification of Pediatric Physiologically Based Pharmacokinetic Models to Facilitate Inclusivity and Diversity in Pediatric Clinical Studies.
Clin Pharmacol Ther
; 113(3): 735-745, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36306419
13.
Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study.
Pharmaceutics
; 15(7)2023 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37514108
14.
Development and application of a PBPK modeling strategy to support antimalarial drug development.
CPT Pharmacometrics Syst Pharmacol
; 12(9): 1335-1346, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37587640
15.
Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2.
Eur J Clin Pharmacol
; 68(6): 951-60, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22258279
16.
Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations.
CPT Pharmacometrics Syst Pharmacol
; 11(3): 373-383, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35174656
17.
Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.
CPT Pharmacometrics Syst Pharmacol
; 11(7): 822-832, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35445542
18.
Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.
Br J Clin Pharmacol
; 71(1): 72-87, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21143503
19.
Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effect of Renal Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given in Combination.
Clin Pharmacokinet
; 60(5): 637-647, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33313995
20.
Using physiologically-based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet.
CPT Pharmacometrics Syst Pharmacol
; 10(9): 1071-1080, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34185436