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1.

Sterile protection against human malaria by chemoattenuated PfSPZ vaccine.

Mordmüller, Benjamin; Surat, Güzin; Lagler, Heimo; Chakravarty, Sumana; Ishizuka, Andrew S; Lalremruata, Albert; Gmeiner, Markus; Campo, Joseph J; Esen, Meral; Ruben, Adam J; Held, Jana; Calle, Carlos Lamsfus; Mengue, Juliana B; Gebru, Tamirat; Ibáñez, Javier; Sulyok, Mihály; James, Eric R; Billingsley, Peter F; Natasha, K C; Manoj, Anita; Murshedkar, Tooba; Gunasekera, Anusha; Eappen, Abraham G; Li, Tao; Stafford, Richard E; Li, Minglin; Felgner, Phil L; Seder, Robert A; Richie, Thomas L; Sim, B Kim Lee; Hoffman, Stephen L; Kremsner, Peter G.

Nature ; 542(7642): 445-449, 2017 02 23.

Artículo en Inglés | MEDLINE | ID: mdl-28199305

2.

Increase of Dose Associated With Decrease in Protection Against Controlled Human Malaria Infection by PfSPZ Vaccine in Tanzanian Adults.

Jongo, Said A; Church, L W Preston; Mtoro, Ali T; Schindler, Tobias; Chakravarty, Sumana; Ruben, Adam J; Swanson, Phillip A; Kassim, Kamaka R; Mpina, Maximillian; Tumbo, Anneth-Mwasi; Milando, Florence A; Qassim, Munira; Juma, Omar A; Bakari, Bakari M; Simon, Beatus; James, Eric R; Abebe, Yonas; Kc, Natasha; Saverino, Elizabeth; Fink, Martina; Cosi, Glenda; Gondwe, Linda; Studer, Fabian; Styers, David; Seder, Robert A; Schindler, Tobias; Billingsley, Peter F; Daubenberger, Claudia; Sim, B Kim Lee; Tanner, Marcel; Richie, Thomas L; Abdulla, Salim; Hoffman, Stephen L.

Clin Infect Dis ; 71(11): 2849-2857, 2020 12 31.

Artículo en Inglés | MEDLINE | ID: mdl-31782768

3.

Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection.

Lyke, Kirsten E; Ishizuka, Andrew S; Berry, Andrea A; Chakravarty, Sumana; DeZure, Adam; Enama, Mary E; James, Eric R; Billingsley, Peter F; Gunasekera, Anusha; Manoj, Anita; Li, Minglin; Ruben, Adam J; Li, Tao; Eappen, Abraham G; Stafford, Richard E; Kc, Natasha; Murshedkar, Tooba; Mendoza, Floreliz H; Gordon, Ingelise J; Zephir, Kathryn L; Holman, LaSonji A; Plummer, Sarah H; Hendel, Cynthia S; Novik, Laura; Costner, Pamela J M; Saunders, Jamie G; Berkowitz, Nina M; Flynn, Barbara J; Nason, Martha C; Garver, Lindsay S; Laurens, Matthew B; Plowe, Christopher V; Richie, Thomas L; Graham, Barney S; Roederer, Mario; Sim, B Kim Lee; Ledgerwood, Julie E; Hoffman, Stephen L; Seder, Robert A.

Proc Natl Acad Sci U S A ; 114(10): 2711-2716, 2017 03 07.

Artículo en Inglés | MEDLINE | ID: mdl-28223498

4.

A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria.

Sirima, Sodiomon B; Ouédraogo, Alphonse; Tiono, Alfred B; Kaboré, Jean M; Bougouma, Edith C; Ouattara, Maurice S; Kargougou, Désiré; Diarra, Amidou; Henry, Noelie; Ouédraogo, Issa N; Billingsley, Peter F; Manoj, Anita; Abebe, Yonas; Kc, Natasha; Ruben, Adam; Richie, Thomas L; James, Eric R; Joshi, Sudhaunshu; Shrestha, Biraj; Strauss, Kathy; Lyke, Kirsten E; Plowe, Christopher V; Potter, Gail E; Cox, Catherine; Jones, Walter; Sim, B Kim Lee; Hoffman, Stephen L; Laurens, Matthew B.

Sci Transl Med ; 14(674): eabj3776, 2022 12 07.

Artículo en Inglés | MEDLINE | ID: mdl-36475905

5.

Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution.

Miura, Takuya; Hidaka, Koushi; Uemura, Tsuyoshi; Kashimoto, Keisuke; Hori, Yuto; Kawasaki, Yuko; Ruben, Adam J; Freire, Ernesto; Kimura, Tooru; Kiso, Yoshiaki.

Bioorg Med Chem Lett ; 20(16): 4836-9, 2010 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-20634066

6.

Safety and Differential Antibody and T-Cell Responses to the Plasmodium falciparum Sporozoite Malaria Vaccine, PfSPZ Vaccine, by Age in Tanzanian Adults, Adolescents, Children, and Infants.

Jongo, Said A; Church, L W Preston; Mtoro, Ali T; Chakravarty, Sumana; Ruben, Adam J; Swanson, Phillip A; Kassim, Kamaka R; Mpina, Maximillian; Tumbo, Anneth-Mwasi; Milando, Florence A; Qassim, Munira; Juma, Omar A; Bakari, Bakari M; Simon, Beatus; James, Eric R; Abebe, Yonas; Kc, Natasha; Saverino, Elizabeth; Gondwe, Linda; Studer, Fabian; Fink, Martina; Cosi, Glenda; El-Khorazaty, Jill; Styers, David; Seder, Robert A; Schindler, Tobias; Billingsley, Peter F; Daubenberger, Claudia; Sim, B Kim Lee; Tanner, Marcel; Richie, Thomas L; Abdulla, Salim; Hoffman, Stephen L.

Am J Trop Med Hyg ; 100(6): 1433-1444, 2019 06.

Artículo en Inglés | MEDLINE | ID: mdl-30994090

7.

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.

Hidaka, Koushi; Kimura, Tooru; Ruben, Adam J; Uemura, Tsuyoshi; Kamiya, Mami; Kiso, Aiko; Okamoto, Tetsuya; Tsuchiya, Yumi; Hayashi, Yoshio; Freire, Ernesto; Kiso, Yoshiaki.

Bioorg Med Chem ; 16(23): 10049-60, 2008 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-18952439

8.

Impact of Sickle Cell Trait and Naturally Acquired Immunity on Uncomplicated Malaria after Controlled Human Malaria Infection in Adults in Gabon.

Lell, Bertrand; Mordmüller, Benjamin; Dejon Agobe, Jean-Claude; Honkpehedji, Josiane; Zinsou, Jeannot; Mengue, Juliana Boex; Loembe, Marguerite Massinga; Adegnika, Ayola Akim; Held, Jana; Lalremruata, Albert; Nguyen, The Trong; Esen, Meral; Kc, Natasha; Ruben, Adam J; Chakravarty, Sumana; Lee Sim, B Kim; Billingsley, Peter F; James, Eric R; Richie, Thomas L; Hoffman, Stephen L; Kremsner, Peter G.

Am J Trop Med Hyg ; 98(2): 508-515, 2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-29260650

9.

Advancing Global Health through Development and Clinical Trials Partnerships: A Randomized, Placebo-Controlled, Double-Blind Assessment of Safety, Tolerability, and Immunogenicity of PfSPZ Vaccine for Malaria in Healthy Equatoguinean Men.

Olotu, Ally; Urbano, Vicente; Hamad, Ali; Eka, Martin; Chemba, Mwajuma; Nyakarungu, Elizabeth; Raso, Jose; Eburi, Esther; Mandumbi, Dolores O; Hergott, Dianna; Maas, Carl D; Ayekaba, Mitoha O; Milang, Diosdado N; Rivas, Matilde R; Schindler, Tobias; Embon, Oscar M; Ruben, Adam J; Saverino, Elizabeth; Abebe, Yonas; Kc, Natasha; James, Eric R; Murshedkar, Tooba; Manoj, Anita; Chakravarty, Sumana; Li, Minglin; Adams, Matthew; Schwabe, Christopher; Segura, J Luis; Daubenberger, Claudia; Tanner, Marcel; Richie, Thomas L; Billingsley, Peter F; Lee Sim, B Kim; Abdulla, Salim; Hoffman, Stephen L.

Am J Trop Med Hyg ; 98(1): 308-318, 2018 01.

Artículo en Inglés | MEDLINE | ID: mdl-29141739

10.

Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults.

Jongo, Said A; Shekalaghe, Seif A; Church, L W Preston; Ruben, Adam J; Schindler, Tobias; Zenklusen, Isabelle; Rutishauser, Tobias; Rothen, Julian; Tumbo, Anneth; Mkindi, Catherine; Mpina, Maximillian; Mtoro, Ali T; Ishizuka, Andrew S; Kassim, Kamaka Ramadhani; Milando, Florence A; Qassim, Munira; Juma, Omar A; Mwakasungula, Solomon; Simon, Beatus; James, Eric R; Abebe, Yonas; Kc, Natasha; Chakravarty, Sumana; Saverino, Elizabeth; Bakari, Bakari M; Billingsley, Peter F; Seder, Robert A; Daubenberger, Claudia; Sim, B Kim Lee; Richie, Thomas L; Tanner, Marcel; Abdulla, Salim; Hoffman, Stephen L.

Am J Trop Med Hyg ; 99(2): 338-349, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-29943719

11.

Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.

Epstein, Judith E; Paolino, Kristopher M; Richie, Thomas L; Sedegah, Martha; Singer, Alexandra; Ruben, Adam J; Chakravarty, Sumana; Stafford, April; Ruck, Richard C; Eappen, Abraham G; Li, Tao; Billingsley, Peter F; Manoj, Anita; Silva, Joana C; Moser, Kara; Nielsen, Robin; Tosh, Donna; Cicatelli, Susan; Ganeshan, Harini; Case, Jessica; Padilla, Debbie; Davidson, Silas; Garver, Lindsey; Saverino, Elizabeth; Murshedkar, Tooba; Gunasekera, Anusha; Twomey, Patrick S; Reyes, Sharina; Moon, James E; James, Eric R; Kc, Natasha; Li, Minglin; Abot, Esteban; Belmonte, Arnel; Hauns, Kevin; Belmonte, Maria; Huang, Jun; Vasquez, Carlos; Remich, Shon; Carrington, Mary; Abebe, Yonas; Tillman, Amy; Hickey, Bradley; Regules, Jason; Villasante, Eileen; Sim, B Kim Lee; Hoffman, Stephen L.

JCI Insight ; 2(1): e89154, 2017 01 12.

Artículo en Inglés | MEDLINE | ID: mdl-28097230

12.

Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial.

Sissoko, Mahamadou S; Healy, Sara A; Katile, Abdoulaye; Omaswa, Freda; Zaidi, Irfan; Gabriel, Erin E; Kamate, Bourama; Samake, Yacouba; Guindo, Merepen A; Dolo, Amagana; Niangaly, Amadou; Niaré, Karamoko; Zeguime, Amatigue; Sissoko, Kourane; Diallo, Hama; Thera, Ismaila; Ding, Kelly; Fay, Michael P; O'Connell, Elise M; Nutman, Thomas B; Wong-Madden, Sharon; Murshedkar, Tooba; Ruben, Adam J; Li, Minglin; Abebe, Yonas; Manoj, Anita; Gunasekera, Anusha; Chakravarty, Sumana; Sim, B Kim Lee; Billingsley, Peter F; James, Eric R; Walther, Michael; Richie, Thomas L; Hoffman, Stephen L; Doumbo, Ogobara; Duffy, Patrick E.

Lancet Infect Dis ; 17(5): 498-509, 2017 05.

Artículo en Inglés | MEDLINE | ID: mdl-28216244

13.

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.

Ishizuka, Andrew S; Lyke, Kirsten E; DeZure, Adam; Berry, Andrea A; Richie, Thomas L; Mendoza, Floreliz H; Enama, Mary E; Gordon, Ingelise J; Chang, Lee-Jah; Sarwar, Uzma N; Zephir, Kathryn L; Holman, LaSonji A; James, Eric R; Billingsley, Peter F; Gunasekera, Anusha; Chakravarty, Sumana; Manoj, Anita; Li, MingLin; Ruben, Adam J; Li, Tao; Eappen, Abraham G; Stafford, Richard E; K C, Natasha; Murshedkar, Tooba; DeCederfelt, Hope; Plummer, Sarah H; Hendel, Cynthia S; Novik, Laura; Costner, Pamela J M; Saunders, Jamie G; Laurens, Matthew B; Plowe, Christopher V; Flynn, Barbara; Whalen, William R; Todd, J P; Noor, Jay; Rao, Srinivas; Sierra-Davidson, Kailan; Lynn, Geoffrey M; Epstein, Judith E; Kemp, Margaret A; Fahle, Gary A; Mikolajczak, Sebastian A; Fishbaugher, Matthew; Sack, Brandon K; Kappe, Stefan H I; Davidson, Silas A; Garver, Lindsey S; Björkström, Niklas K; Nason, Martha C.

Nat Med ; 22(6): 614-23, 2016 06.

Artículo en Inglés | MEDLINE | ID: mdl-27158907

14.

Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection.

Lyke, Kirsten E; Laurens, Matthew B; Strauss, Kathy; Adams, Matthew; Billingsley, Peter F; James, Eric; Manoj, Anita; Chakravarty, Sumana; Plowe, Christopher V; Li, Ming Lin; Ruben, Adam; Edelman, Robert; Green, Michael; Dube, Tina J; Sim, B Kim Lee; Hoffman, Stephen L.

Am J Trop Med Hyg ; 93(6): 1274-1284, 2015 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-26416102

15.

Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites.

Shekalaghe, Seif; Rutaihwa, Mastidia; Billingsley, Peter F; Chemba, Mwajuma; Daubenberger, Claudia A; James, Eric R; Mpina, Maximillian; Ali Juma, Omar; Schindler, Tobias; Huber, Eric; Gunasekera, Anusha; Manoj, Anita; Simon, Beatus; Saverino, Elizabeth; Church, L W Preston; Hermsen, Cornelus C; Sauerwein, Robert W; Plowe, Christopher; Venkatesan, Meera; Sasi, Philip; Lweno, Omar; Mutani, Paul; Hamad, Ali; Mohammed, Ali; Urassa, Alwisa; Mzee, Tutu; Padilla, Debbie; Ruben, Adam; Sim, B Kim Lee; Tanner, Marcel; Abdulla, Salim; Hoffman, Stephen L.

Am J Trop Med Hyg ; 91(3): 471-480, 2014 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-25070995

16.

Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine.

Seder, Robert A; Chang, Lee-Jah; Enama, Mary E; Zephir, Kathryn L; Sarwar, Uzma N; Gordon, Ingelise J; Holman, LaSonji A; James, Eric R; Billingsley, Peter F; Gunasekera, Anusha; Richman, Adam; Chakravarty, Sumana; Manoj, Anita; Velmurugan, Soundarapandian; Li, MingLin; Ruben, Adam J; Li, Tao; Eappen, Abraham G; Stafford, Richard E; Plummer, Sarah H; Hendel, Cynthia S; Novik, Laura; Costner, Pamela J M; Mendoza, Floreliz H; Saunders, Jamie G; Nason, Martha C; Richardson, Jason H; Murphy, Jittawadee; Davidson, Silas A; Richie, Thomas L; Sedegah, Martha; Sutamihardja, Awalludin; Fahle, Gary A; Lyke, Kirsten E; Laurens, Matthew B; Roederer, Mario; Tewari, Kavita; Epstein, Judith E; Sim, B Kim Lee; Ledgerwood, Julie E; Graham, Barney S; Hoffman, Stephen L.

Science ; 341(6152): 1359-65, 2013 Sep 20.

Artículo en Inglés | MEDLINE | ID: mdl-23929949

17.

Of mice and mics.

Ruben, Adam.

Science ; 352(6281): 110, 2016 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-27034375

18.

Corrigendum: Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.

Ishizuka, Andrew S; Lyke, Kirsten E; DeZure, Adam; Berry, Andrea A; Richie, Thomas L; Mendoza, Floreliz H; Enama, Mary E; Gordon, Ingelise J; Chang, Lee-Jah; Sarwar, Uzma N; Zephir, Kathryn L; Holman, LaSonji A; James, Eric R; Billingsley, Peter F; Gunasekera, Anusha; Chakravarty, Sumana; Manoj, Anita; Li, MingLin; Ruben, Adam J; Li, Tao; Eappen, Abraham G; Stafford, Richard E; K C, Natasha; Murshedkar, Tooba; DeCederfelt, Hope; Plummer, Sarah H; Hendel, Cynthia S; Novik, Laura; Costner, Pamela J M; Saunders, Jamie G; Laurens, Matthew B; Plowe, Christopher V; Flynn, Barbara; Whalen, William R; Todd, J P; Noor, Jay; Rao, Srinivas; Sierra-Davidson, Kailan; Lynn, Geoffrey M; Epstein, Judith E; Kemp, Margaret A; Fahle, Gary A; Mikolajczak, Sebastian A; Fishbaugher, Matthew; Sack, Brandon K; Kappe, Stefan H I; Davidson, Silas A; Garver, Lindsey S; Björkström, Niklas K; Nason, Martha C.

Nat Med ; 22(6): 692, 2016 06 07.

Artículo en Inglés | MEDLINE | ID: mdl-27270781

19.

Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.

Hidaka, Koushi; Kimura, Tooru; Tsuchiya, Yumi; Kamiya, Mami; Ruben, Adam J; Freire, Ernesto; Hayashi, Yoshio; Kiso, Yoshiaki.

Bioorg Med Chem Lett ; 17(11): 3048-52, 2007 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-17400453

20.

Overcoming roadblocks in lead optimization: a thermodynamic perspective.

Ruben, Adam J; Kiso, Yoshiaki; Freire, Ernesto.

Chem Biol Drug Des ; 67(1): 2-4, 2006 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-16492143

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