Detalles de la búsqueda
1.
Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans.
Xenobiotica
; 52(3): 240-253, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-35382680
2.
Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).
Bioorg Med Chem
; 41: 116205, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34000509
3.
Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.
Drug Metab Dispos
; 47(8): 874-882, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31182423
4.
Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.
Drug Metab Dispos
; 44(2): 209-19, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26608081
5.
Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies.
Drug Metab Dispos
; 42(10): 1627-39, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25053618
6.
The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.
Drug Metab Dispos
; 42(4): 759-73, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24464803
7.
Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor.
Drug Metab Dispos
; 41(7): 1375-88, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23610086
8.
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.
J Med Chem
; 66(5): 3195-3211, 2023 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36802610
9.
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
Drug Metab Dispos
; 40(11): 2143-61, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22896728
10.
Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.
Drug Metab Dispos
; 40(5): 1051-65, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22357286
11.
Insights into the novel hydrolytic mechanism of a diethyl 2-phenyl-2-(2-arylacetoxy)methyl malonate ester-based microsomal triglyceride transfer protein (MTP) inhibitor.
Chem Res Toxicol
; 25(10): 2138-52, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22989032
12.
Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR.
Drug Metab Dispos
; 39(3): 433-40, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21098098
13.
Intrinsic electrophilicity of a 4-substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine derivative: structural characterization of glutathione conjugates in vitro.
Chem Res Toxicol
; 24(2): 269-78, 2011 Feb 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-21288051
14.
Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics.
Drug Metab Dispos
; 38(8): 1381-91, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20478852
15.
Species differences in the biotransformation of an alpha 4 beta 2 nicotinic acetylcholine receptor partial agonist: the effects of distinct glucuronide metabolites on overall compound disposition.
Drug Metab Dispos
; 38(2): 292-301, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19910512
16.
Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.
Chem Res Toxicol
; 23(6): 1115-26, 2010 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-20507089
17.
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J Med Chem
; 63(22): 13546-13560, 2020 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32910646
18.
Biotransformation of an alpha4beta2 nicotinic acetylcholine receptor partial agonist in sprague-dawley rats and the dispositional characterization of its N-carbamoyl glucuronide metabolite.
Drug Metab Dispos
; 37(7): 1480-9, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19339375
19.
Distribution, Metabolism, and Excretion of Gedatolisib in Healthy Male Volunteers After a Single Intravenous Infusion.
Clin Pharmacol Drug Dev
; 8(1): 22-31, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30256541
20.
In vitro metabolism and covalent binding of enol-carboxamide derivatives and anti-inflammatory agents sudoxicam and meloxicam: insights into the hepatotoxicity of sudoxicam.
Chem Res Toxicol
; 21(9): 1890-9, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18707140