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1.
A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation.
Br J Clin Pharmacol
; 90(4): 1027-1035, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-37990600
2.
Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction.
Europace
; 23(11): 1847-1859, 2021 11 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34080619
3.
Arrhythmia development during inhibition of small-conductance calcium-activated potassium channels in acute myocardial infarction in a porcine model.
Europace
; 21(10): 1584-1593, 2019 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31408093
4.
pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts.
Pflugers Arch
; 468(4): 643-54, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26729267
5.
Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy.
J Cardiovasc Pharmacol
; 66(5): 441-8, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25830485
6.
Cardiac ion channels and mechanisms for protection against atrial fibrillation.
Rev Physiol Biochem Pharmacol
; 162: 1-58, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-21987061
7.
Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial.
Nat Med
; 30(1): 106-111, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38092897
8.
Evidence for a common pharmacological interaction site on K(Ca)2 channels providing both selective activation and selective inhibition of the human K(Ca)2.1 subtype.
Mol Pharmacol
; 81(2): 210-9, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22046005
9.
Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.
Mol Pharmacol
; 79(6): 899-909, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21363929
10.
The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca(2+)-activated K(+) channels.
J Cardiovasc Pharmacol
; 57(6): 672-81, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21394037
11.
Increased fibroblast accumulation in the equine heart following persistent atrial fibrillation.
Int J Cardiol Heart Vasc
; 35: 100842, 2021 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-34355058
12.
Inhibition of Small-Conductance Calcium-Activated Potassium Current (I K,Ca) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation.
Front Physiol
; 12: 614483, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33633584
13.
The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs.
Front Pharmacol
; 11: 159, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32180722
14.
Inhibition of KCa2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia.
Front Pharmacol
; 11: 749, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32508659
15.
First Clinical Study with AP30663 - a KCa 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation.
Clin Transl Sci
; 13(6): 1336-1344, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32725783
16.
Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man.
Front Pharmacol
; 11: 610, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32477117
17.
Effect of selective IK,ACh inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation.
Br J Pharmacol
; 177(16): 3778-3794, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32436234
18.
The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts.
Front Pharmacol
; 10: 668, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31275147
19.
2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels.
Front Pharmacol
; 9: 1409, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30559671
20.
A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels.
Br J Pharmacol
; 174(23): 4396-4408, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28925012