Detalles de la búsqueda
1.
New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling.
Molecules
; 29(3)2024 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38338326
2.
Novel Epoxides of Soloxolone Methyl: An Effect of the Formation of Oxirane Ring and Stereoisomerism on Cytotoxic Profile, Anti-Metastatic and Anti-Inflammatory Activities In Vitro and In Vivo.
Int J Mol Sci
; 23(11)2022 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35682893
3.
Soloxolone methyl, as a 18ßH-glycyrrhetinic acid derivate, may result in endoplasmic reticulum stress to induce apoptosis in breast cancer cells.
Bioorg Med Chem
; 30: 115963, 2021 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33383441
4.
New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2.
Molecules
; 27(1)2021 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35011303
5.
Dual Effect of Soloxolone Methyl on LPS-Induced Inflammation In Vitro and In Vivo.
Int J Mol Sci
; 21(21)2020 Oct 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-33114200
6.
Novel 3'-Substituted-1',2',4'-Oxadiazole Derivatives of 18ßH-Glycyrrhetinic Acid and Their O-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo.
Int J Mol Sci
; 21(10)2020 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32429154
7.
Cyano Enone-Bearing Triterpenoid Soloxolone Methyl Inhibits Epithelial-Mesenchymal Transition of Human Lung Adenocarcinoma Cells In Vitro and Metastasis of Murine Melanoma In Vivo.
Molecules
; 25(24)2020 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33327637
8.
Trioxolone Methyl, a Novel Cyano Enone-Bearing 18ßH-Glycyrrhetinic Acid Derivative, Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice.
Molecules
; 25(10)2020 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32455822
9.
Novel Derivatives of Deoxycholic Acid Bearing Linear Aliphatic Diamine and Aminoalcohol Moieties and their Cyclic Analogs at the C3 Position: Synthesis and Evaluation of Their In Vitro Antitumor Potential.
Molecules
; 24(14)2019 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31330911
10.
Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.
Molecules
; 23(3)2018 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-29562592
11.
Novel derivatives of deoxycholic acid bearing aliphatic or cyclic diamine moieties at the C-3 position: Synthesis and evaluation of anti-proliferative activity.
Bioorg Med Chem Lett
; 27(16): 3755-3759, 2017 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28688958
12.
Synthesis and biological activity of novel deoxycholic acid derivatives.
Bioorg Med Chem
; 23(15): 5022-5034, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26037611
13.
Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells.
Bioorg Med Chem
; 22(1): 585-93, 2014 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24268542
14.
Protective effect of soloxolone derivatives in carrageenan- and LPS-driven acute inflammation: Pharmacological profiling and their effects on key inflammation-related processes.
Biomed Pharmacother
; 159: 114231, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-36640672
15.
Soloxolone Methyl Reduces the Stimulatory Effect of Leptin on the Aggressive Phenotype of Murine Neuro2a Neuroblastoma Cells via the MAPK/ERK1/2 Pathway.
Pharmaceuticals (Basel)
; 16(10)2023 Sep 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37895840
16.
A Novel 3-meta-Pyridine-1,2,4-oxadiazole Derivative of Glycyrrhetinic Acid as a Safe and Promising Candidate for Overcoming P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells.
ACS Omega
; 8(51): 48813-48824, 2023 Dec 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38162726
17.
Soloxolone methyl induces apoptosis and oxidative/ER stress in breast cancer cells and target cancer stem cell population.
Turk J Biol
; 47(4): 247-261, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38152618
18.
Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo.
Pharmaceuticals (Basel)
; 15(5)2022 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35631429
19.
Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid derivatives.
Chembiochem
; 12(5): 784-94, 2011 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-21328513
20.
Deoxycholic acid as a molecular scaffold for tyrosyl-DNA phosphodiesterase 1 inhibition: A synthesis, structure-activity relationship and molecular modeling study.
Steroids
; 165: 108771, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33221302