Detalles de la búsqueda
1.
Survey of pharmaceutical industry's best practices around in vitro transporter assessment and Implications for Drug Development: Considerations from the IQ Transporter Working Group.
Drug Metab Dispos
; 2024 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38697852
2.
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human.
Xenobiotica
; 54(2): 64-74, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38197324
3.
Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent ß-Sparing PI3K Inhibitor in Rats, Dogs, and Humans.
Drug Metab Dispos
; 51(4): 436-450, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36623882
4.
Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation.
Drug Metab Dispos
; 51(7): 862-872, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37059472
5.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35065235
6.
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Drug Metab Dispos
; 49(2): 159-168, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33051248
7.
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans.
Xenobiotica
; 51(7): 796-810, 2021 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-33938357
8.
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.
Drug Metab Dispos
; 47(4): 350-357, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30622164
9.
Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor.
Br J Clin Pharmacol
; 85(8): 1751-1760, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30973970
10.
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg Med Chem Lett
; 29(16): 2294-2301, 2019 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31307887
11.
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.
Drug Metab Dispos
; 46(2): 189-196, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29138286
12.
Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
Drug Metab Dispos
; 46(7): 943-952, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29695616
13.
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition.
Toxicol Appl Pharmacol
; 338: 204-213, 2018 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29146462
14.
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat Chem Biol
; 12(10): 779-86, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27479743
15.
Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.
Mol Pharm
; 15(11): 5103-5113, 2018 11 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30222362
16.
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.
Mol Pharmacol
; 89(5): 492-504, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26893303
17.
Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.
Drug Metab Dispos
; 44(11): 1752-1758, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27543206
18.
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.
Drug Metab Dispos
; 44(12): 1881-1889, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27638506
19.
Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics.
Drug Metab Dispos
; 43(3): 367-74, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25534768
20.
Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.
Drug Metab Dispos
; 43(2): 284-8, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25488931