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1.
Small-Scale Panel Comprising Diverse Gene Family Targets To Evaluate Compound Promiscuity.
Chem Res Toxicol
; 33(1): 154-161, 2020 01 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31461269
2.
Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.
J Biol Chem
; 293(18): 6776-6790, 2018 05 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29545311
3.
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.
Bioorg Med Chem Lett
; 29(21): 126641, 2019 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31526603
4.
Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER).
Chem Pharm Bull (Tokyo)
; 67(3): 203-209, 2019 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30369550
5.
Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein-Protein Interaction Interface.
Biochemistry
; 57(8): 1369-1379, 2018 02 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-29293322
6.
Universal and Quantitative Method To Evaluate Inhibitor Potency for Cysteinome Proteins Using a Nonspecific Activity-Based Protein Profiling Probe.
Biochemistry
; 56(23): 2921-2927, 2017 06 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28520393
7.
Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.
Cancer Sci
; 108(8): 1657-1666, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28556300
8.
K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.
Biochem Biophys Res Commun
; 484(3): 605-611, 2017 03 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28153726
9.
Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging.
Bioorg Med Chem Lett
; 27(12): 2757-2761, 2017 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28457754
10.
Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact/KI) by Means of an Endpoint Competition Assay.
Angew Chem Int Ed Engl
; 54(47): 14099-102, 2015 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-26426864
11.
A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay.
Bioorg Med Chem Lett
; 24(24): 5836-5839, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25452002
12.
Single-molecule study on the decay process of the football-shaped GroEL-GroES complex using zero-mode waveguides.
J Biol Chem
; 285(30): 23159-64, 2010 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-20511221
13.
Denatured proteins facilitate the formation of the football-shaped GroEL-(GroES)2 complex.
Biochem J
; 427(2): 247-54, 2010 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-20121703
14.
Identification of 2,6-Disubstituted 3H-Imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived Induced Pluripotent Stem Cells.
J Med Chem
; 62(20): 9175-9187, 2019 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31550153
15.
Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode.
ACS Med Chem Lett
; 10(10): 1498-1503, 2019 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31620240
16.
Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.
Sci Rep
; 8(1): 13549, 2018 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30202081
17.
Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
J Med Chem
; 61(17): 7710-7728, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30067358
18.
High-Throughput Quantitative Intrinsic Thiol Reactivity Evaluation Using a Fluorescence-Based Competitive Endpoint Assay.
SLAS Discov
; 22(9): 1168-1174, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28426937
19.
Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.
ACS Med Chem Lett
; 8(7): 732-736, 2017 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28740607
20.
Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.
ACS Med Chem Lett
; 8(10): 1042-1047, 2017 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29057048