Detalles de la búsqueda
1.
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.
Bioorg Med Chem Lett
; 22(5): 2094-8, 2012 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22300661
2.
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.
Bioorg Med Chem
; 20(2): 866-76, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22197397
3.
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
Bioorg Med Chem Lett
; 21(13): 3935-8, 2011 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21636271
4.
Proteasomal inhibition and apoptosis regulatory changes in human isolated lymphocytes: the synergistic role of dopamine.
J Cell Biochem
; 103(3): 877-85, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17647258
5.
Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies.
Bioorg Med Chem Lett
; 18(21): 5777-80, 2008 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18842407
6.
Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity.
J Med Chem
; 50(20): 5034-8, 2007 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17803291
7.
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains.
J Med Chem
; 50(22): 5412-24, 2007 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17910429
8.
Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants.
J Med Chem
; 50(26): 6580-95, 2007 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18052319
9.
Oxidative stress and pro-apoptotic conditions in a rodent model of Wilson's disease.
Biochim Biophys Acta
; 1741(3): 325-30, 2005 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-16081251
10.
Brain monoaminergic neurotransmission parameters in weanling rats after perinatal exposure to methylmercury and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153).
Brain Res
; 1112(1): 91-8, 2006 Sep 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-16904659
11.
Dopaminergic modulation of oxidative stress and apoptosis in human peripheral blood lymphocytes: evidence for a D1-like receptor-dependent protective effect.
Free Radic Biol Med
; 36(10): 1233-40, 2004 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15110388
12.
Dopaminergic modulation of apoptosis in human peripheral blood mononuclear cells: possible relevance for Parkinson's disease.
Ann N Y Acad Sci
; 1010: 679-82, 2003 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15033811
13.
In vitro anti-inflammatory activity of selected oxalate-degrading probiotic bacteria: potential applications in the prevention and treatment of hyperoxaluria.
J Food Sci
; 79(3): M384-90, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24471378
14.
The power of enzyme kinetics in the drug development process.
Curr Pharm Biotechnol
; 14(5): 551-60, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-22429137
15.
Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors.
ChemMedChem
; 7(5): 883-96, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22419605
16.
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.
J Med Chem
; 55(14): 6634-8, 2012 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22712652
17.
2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies.
J Med Chem
; 55(7): 3558-62, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22428851
18.
Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates.
Antivir Chem Chemother
; 22(3): 107-18, 2011 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-22095519
19.
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.
J Med Chem
; 54(6): 1587-98, 2011 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21366296
20.
Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level.
J Med Chem
; 54(8): 3091-6, 2011 Apr 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-21438533