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1.
Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.
Bioorg Med Chem Lett
; 19(16): 4747-51, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19576766
2.
Pharmacological effects of nicotine on norepinephrine metabolism in rat brown adipose tissue: relevance to nicotinic therapies for smoking cessation.
Toxicol Pathol
; 36(4): 568-75, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18467676
3.
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
J Med Chem
; 49(14): 4425-36, 2006 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-16821801
4.
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.
J Med Chem
; 48(10): 3474-7, 2005 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-15887955
5.
Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.
ACS Med Chem Lett
; 6(4): 450-4, 2015 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25893048
6.
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
J Med Chem
; 53(3): 1222-37, 2010 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20043678
7.
3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.
Bioorg Med Chem Lett
; 15(22): 4889-97, 2005 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16171993
8.
In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.
Bioorg Med Chem Lett
; 15(12): 2974-9, 2005 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15908213
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